The Mark Coventry Award: Higher Tissue Concentrations of Vancomycin With Low-dose Intraosseous Regional Versus Systemic Prophylaxis in TKA: A Randomized Trial

Background In response to increasing antibiotic resistance, vancomycin has been proposed as an alternative prophylactic agent in TKA. However, vancomycin requires a prolonged administration time, risks promoting further antibiotic resistance, and can cause systemic toxicity. Intraosseous regional ad...

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Veröffentlicht in:	Clinical orthopaedics and related research 2014-01, Vol.472 (1), p.57-65
Hauptverfasser:	Young, Simon W., Zhang, Mei, Freeman, Joshua T., Mutu-Grigg, John, Pavlou, Paul, Moore, Grant A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - methods Arthroplasty, Replacement, Knee - methods Awards and Prizes Conservative Orthopedics Female Humans Infusions, Intraosseous Infusions, Intravenous Knee Male Medicine Medicine & Public Health Middle Aged Orthopedics Sports Medicine Surgery Surgical Orthopedics Symposium: 2013 Knee Society Proceedings Vancomycin - administration & dosage Vancomycin - therapeutic use
Online-Zugang:	Volltext
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