Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disru...

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Veröffentlicht in:	Nature (London) 1992-10, Vol.359 (6397), p.693-699
Hauptverfasser:	Shull, Marcia M, Ormsby, Ilona, Kier, Ann B, Pawlowski, Sharon, Diebold, Ronald J, Yin, Moying, Allen, Ruth, Sidman, Charles, Proetzel, Gabriele, Calvin, Dawn, Annunziata, Nikki, Doetschman, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Experimental and animal immunopathology. Animal models Humanities and Social Sciences Immunity (Disease) Immunopathology Medical research Medical sciences multidisciplinary Rodents Science Science (multidisciplinary) Stem cells
Online-Zugang:	Volltext
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