Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature
Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease (pIBD). Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to...
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Veröffentlicht in: | Clinical infectious diseases 2013-11, Vol.57 (9), p.1318-1330 |
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description | Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease (pIBD). Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to other disease-modifying antirheumatic drugs. We report herein a systematic literature review detailing the epidemiology and types of infections reported in children with JIA and pIBD treated with TNF-α inhibitors. The most frequently reported infections were mild and characterized as viral in etiology. Severe bacterial and fungal infections also occurred, but were less common and possibly associated with intrinsic risk factors and concurrent immunosuppressive therapy. Few pediatric patients developed Mycobacterium tuberculosis, likely due to effective screening. There were 8 infectious fatalities in children treated with TNF-α inhibitors. Overall, although rare, serious infections occur in immunocompromised children and adolescents with JIA and pIBD receiving TNF-α inhibitors. |
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Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to other disease-modifying antirheumatic drugs. We report herein a systematic literature review detailing the epidemiology and types of infections reported in children with JIA and pIBD treated with TNF-α inhibitors. The most frequently reported infections were mild and characterized as viral in etiology. Severe bacterial and fungal infections also occurred, but were less common and possibly associated with intrinsic risk factors and concurrent immunosuppressive therapy. Few pediatric patients developed Mycobacterium tuberculosis, likely due to effective screening. There were 8 infectious fatalities in children treated with TNF-α inhibitors. Overall, although rare, serious infections occur in immunocompromised children and adolescents with JIA and pIBD receiving TNF-α inhibitors.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/cit489</identifier><identifier>PMID: 23899685</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Oxford: OXFORD UNIVERSITY PRESS</publisher><subject>Adolescent ; Arthritis, Juvenile - complications ; Arthritis, Juvenile - drug therapy ; Bacterial Infections - epidemiology ; Biological and medical sciences ; Child ; Child, Preschool ; Diseases of the osteoarticular system ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunocompromised Host ; IMMUNOCOMPROMISED HOSTS ; Immunologic Factors - adverse effects ; Immunologic Factors - therapeutic use ; Infant ; Infectious diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory joint diseases ; Invited ; Medical sciences ; Mycoses - epidemiology ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Virus Diseases - epidemiology</subject><ispartof>Clinical infectious diseases, 2013-11, Vol.57 (9), p.1318-1330</ispartof><rights>Copyright © 2013 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2014 INIST-CNRS</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24030957$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24030957$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27834494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23899685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toussi, Sima S.</creatorcontrib><creatorcontrib>Pan, Nancy</creatorcontrib><creatorcontrib>Walters, Heather M.</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><title>Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease (pIBD). Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to other disease-modifying antirheumatic drugs. We report herein a systematic literature review detailing the epidemiology and types of infections reported in children with JIA and pIBD treated with TNF-α inhibitors. The most frequently reported infections were mild and characterized as viral in etiology. Severe bacterial and fungal infections also occurred, but were less common and possibly associated with intrinsic risk factors and concurrent immunosuppressive therapy. Few pediatric patients developed Mycobacterium tuberculosis, likely due to effective screening. There were 8 infectious fatalities in children treated with TNF-α inhibitors. Overall, although rare, serious infections occur in immunocompromised children and adolescents with JIA and pIBD receiving TNF-α inhibitors.</description><subject>Adolescent</subject><subject>Arthritis, Juvenile - complications</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Bacterial Infections - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of the osteoarticular system</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>IMMUNOCOMPROMISED HOSTS</subject><subject>Immunologic Factors - adverse effects</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory joint diseases</subject><subject>Invited</subject><subject>Medical sciences</subject><subject>Mycoses - epidemiology</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Virus Diseases - epidemiology</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcFu1DAQhiMEoqVw4Q7yhWOKE8eJwwFpu1BYtAIJFnGMJvaEzCqJV7Z3q73xDjxJ34An6EPwJLhsoXCwxuP5_8_SP0nyOOOnGa_Fc00mnlCo-k5ynElRpaWss7vxzqVKCyXUUfLA-zXnWaa4vJ8c5ULVdankcfJjMXWoA9nJM5rYvKfBOJwYTIbNjB3Qa5yCZ18o9OzddocTDcgWhuwGQk-azVzoHQXyvy2RNsA4QrBuz87sBQ7sFXkEj2zlEAKaA2m1Ha1j71E766P1HHR0_Pz2_eoyInpqKbb-Bfu09wEjLf7zEXeEF8x2LPTIlhTQQdg6fJjc62Dw-OimniSfz1-v5m_T5Yc3i_lsma7zQoU0F7ItjUAsWtlpyDNeKlW0bS0ESm661sSw2go1SNmJNpem1BJkXekygyo-nSQvD9zNth3RXKfiYGg2jkZw-8YCNf9PJuqbr3bXCKVULngEPP0X8Nf5ZxdR8OxGAF7D0DmYNPlbXaVEUdRF1D056NY-pnQ7L7jgtazEL-XPqmY</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Toussi, Sima S.</creator><creator>Pan, Nancy</creator><creator>Walters, Heather M.</creator><creator>Walsh, Thomas J.</creator><general>OXFORD UNIVERSITY PRESS</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20131101</creationdate><title>Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature</title><author>Toussi, Sima S. ; Pan, Nancy ; Walters, Heather M. ; Walsh, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j248t-235b6d3ee4b5fca2106884bb933e50dfbd105b7eca55f3b25d6c5a597c61a75f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Arthritis, Juvenile - complications</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Bacterial Infections - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of the osteoarticular system</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>IMMUNOCOMPROMISED HOSTS</topic><topic>Immunologic Factors - adverse effects</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - drug therapy</topic><topic>Inflammatory joint diseases</topic><topic>Invited</topic><topic>Medical sciences</topic><topic>Mycoses - epidemiology</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Virus Diseases - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toussi, Sima S.</creatorcontrib><creatorcontrib>Pan, Nancy</creatorcontrib><creatorcontrib>Walters, Heather M.</creatorcontrib><creatorcontrib>Walsh, Thomas J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toussi, Sima S.</au><au>Pan, Nancy</au><au>Walters, Heather M.</au><au>Walsh, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>57</volume><issue>9</issue><spage>1318</spage><epage>1330</epage><pages>1318-1330</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease (pIBD). Adult studies indicate that TNF-α inhibitors lead to an increased risk of serious infections compared to other disease-modifying antirheumatic drugs. We report herein a systematic literature review detailing the epidemiology and types of infections reported in children with JIA and pIBD treated with TNF-α inhibitors. The most frequently reported infections were mild and characterized as viral in etiology. Severe bacterial and fungal infections also occurred, but were less common and possibly associated with intrinsic risk factors and concurrent immunosuppressive therapy. Few pediatric patients developed Mycobacterium tuberculosis, likely due to effective screening. There were 8 infectious fatalities in children treated with TNF-α inhibitors. Overall, although rare, serious infections occur in immunocompromised children and adolescents with JIA and pIBD receiving TNF-α inhibitors.</abstract><cop>Oxford</cop><pub>OXFORD UNIVERSITY PRESS</pub><pmid>23899685</pmid><doi>10.1093/cid/cit489</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Arthritis, Juvenile - complications Arthritis, Juvenile - drug therapy Bacterial Infections - epidemiology Biological and medical sciences Child Child, Preschool Diseases of the osteoarticular system Gastroenterology. Liver. Pancreas. Abdomen Humans Immunocompromised Host IMMUNOCOMPROMISED HOSTS Immunologic Factors - adverse effects Immunologic Factors - therapeutic use Infant Infectious diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy Inflammatory joint diseases Invited Medical sciences Mycoses - epidemiology Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Necrosis Factor-alpha - antagonists & inhibitors Virus Diseases - epidemiology |
title | Infections in Children and Adolescents With Juvenile Idiopathic Arthritis and Inflammatory Bowel Disease Treated With Tumor Necrosis Factor–α Inhibitors: Systematic Review of the Literature |
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