A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice
Abstract In rodents, many aspects of sociosexual behavior are mediated by chemosignals released by opposite-sex conspecifics. These chemosignals are relayed via the main (MOS) and accessory olfactory systems (AOS) to the medial amygdala (Me). The Me is subdivided into anterior (MeA) and posterior (M...
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| Veröffentlicht in: | Brain research 2014-01, Vol.1543, p.101-108 |
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| creator | DiBenedictis, Brett T Helfand, Alexander I Baum, Michael J Cherry, James A |
| description | Abstract In rodents, many aspects of sociosexual behavior are mediated by chemosignals released by opposite-sex conspecifics. These chemosignals are relayed via the main (MOS) and accessory olfactory systems (AOS) to the medial amygdala (Me). The Me is subdivided into anterior (MeA) and posterior (MeP) subnuclei, and lesions targeting these regions have different effects on proceptive courtship behaviors in female mice. Differential behavioral effects of MeA vs. MeP lesions could reflect a difference in the projections of neurons located in these Me subnuclei. To examine this question, we injected female mice with the anterograde tracer, Fluoro-Ruby into either the MeA or MeP and quantified labeled puncta in 11 forebrain target sites implicated in courtship behaviors using confocal fluorescence microscopy. We found that the MeP more densely innervates the medial and intermediate regions of the posterior bed nucleus of the stria terminalis (pBNST) and the posteromedial cortical amygdala (PMCo), while the MeA more densely innervates the horizontal diagonal band of Broca (HDB) and the medial olfactory tubercle (mOT), a region that may be a component of the circuitry responsible for olfactory-mediated motivated behaviors. |
| doi_str_mv | 10.1016/j.brainres.2013.10.046 |
| format | Article |
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These chemosignals are relayed via the main (MOS) and accessory olfactory systems (AOS) to the medial amygdala (Me). The Me is subdivided into anterior (MeA) and posterior (MeP) subnuclei, and lesions targeting these regions have different effects on proceptive courtship behaviors in female mice. Differential behavioral effects of MeA vs. MeP lesions could reflect a difference in the projections of neurons located in these Me subnuclei. To examine this question, we injected female mice with the anterograde tracer, Fluoro-Ruby into either the MeA or MeP and quantified labeled puncta in 11 forebrain target sites implicated in courtship behaviors using confocal fluorescence microscopy. We found that the MeP more densely innervates the medial and intermediate regions of the posterior bed nucleus of the stria terminalis (pBNST) and the posteromedial cortical amygdala (PMCo), while the MeA more densely innervates the horizontal diagonal band of Broca (HDB) and the medial olfactory tubercle (mOT), a region that may be a component of the circuitry responsible for olfactory-mediated motivated behaviors.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2013.10.046</identifier><identifier>PMID: 24262912</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amygdala - anatomy & histology ; Amygdala - metabolism ; Animals ; Anterograde tracing ; Axon terminal ; Biological and medical sciences ; Dextrans - metabolism ; Efferent Pathways - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Medial amygdala ; Mice ; Neurology ; Olfactory ; Olfactory Pathways - cytology ; Olfactory Pathways - physiology ; Olfactory system and olfaction. Gustatory system and gustation ; Prosencephalon - cytology ; Prosencephalon - physiology ; Rhodamines - metabolism ; Septal Nuclei - cytology ; Sociosexual behavior ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2014-01, Vol.1543, p.101-108</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier B.V. All rights reserved.</rights><rights>2013 Elsevier B.V. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-4c23fc036e4b6eca1938c4fd209949f4130d9b381042c6f5198d31f0dfbe257b3</citedby><cites>FETCH-LOGICAL-c655t-4c23fc036e4b6eca1938c4fd209949f4130d9b381042c6f5198d31f0dfbe257b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000689931301456X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28084222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24262912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiBenedictis, Brett T</creatorcontrib><creatorcontrib>Helfand, Alexander I</creatorcontrib><creatorcontrib>Baum, Michael J</creatorcontrib><creatorcontrib>Cherry, James A</creatorcontrib><title>A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract In rodents, many aspects of sociosexual behavior are mediated by chemosignals released by opposite-sex conspecifics. These chemosignals are relayed via the main (MOS) and accessory olfactory systems (AOS) to the medial amygdala (Me). The Me is subdivided into anterior (MeA) and posterior (MeP) subnuclei, and lesions targeting these regions have different effects on proceptive courtship behaviors in female mice. Differential behavioral effects of MeA vs. MeP lesions could reflect a difference in the projections of neurons located in these Me subnuclei. To examine this question, we injected female mice with the anterograde tracer, Fluoro-Ruby into either the MeA or MeP and quantified labeled puncta in 11 forebrain target sites implicated in courtship behaviors using confocal fluorescence microscopy. We found that the MeP more densely innervates the medial and intermediate regions of the posterior bed nucleus of the stria terminalis (pBNST) and the posteromedial cortical amygdala (PMCo), while the MeA more densely innervates the horizontal diagonal band of Broca (HDB) and the medial olfactory tubercle (mOT), a region that may be a component of the circuitry responsible for olfactory-mediated motivated behaviors.</description><subject>Amygdala - anatomy & histology</subject><subject>Amygdala - metabolism</subject><subject>Animals</subject><subject>Anterograde tracing</subject><subject>Axon terminal</subject><subject>Biological and medical sciences</subject><subject>Dextrans - metabolism</subject><subject>Efferent Pathways - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Medial amygdala</subject><subject>Mice</subject><subject>Neurology</subject><subject>Olfactory</subject><subject>Olfactory Pathways - cytology</subject><subject>Olfactory Pathways - physiology</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Prosencephalon - cytology</subject><subject>Prosencephalon - physiology</subject><subject>Rhodamines - metabolism</subject><subject>Septal Nuclei - cytology</subject><subject>Sociosexual behavior</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9uEzEQxlcIREPhFaq9IHFJ8L849qWiqtqCVIkDIHGzvN5xO2HXTu3dSHkBnhuvkpTCpSd7PN98Hvs3VXVGyYISKj-uF02yGBLkBSOUl8MFEfJFNaNqxeaSCfKymhFC5FxpzU-qNzmvS8i5Jq-rEyaYZJqyWfX7on4YbRhwsANuoXax39iEOYY6-nq4hxq8hwRhqDcprsENGEM-5kohJIypbNp6E_MhymPT4hbzU2kPLdqutv3urrWdrTHUHnrblQw6eFu98rbL8O6wnlY_rq--X36e3369-XJ5cTt3crkc5sIx7h3hEkQjwVmquXLCt4xoLbQXlJNWN1xRIpiTfkm1ajn1pPUNsOWq4afV-d53MzalI1felWxnNgl7m3YmWjT_ZgLem7u4NVwpRSkpBh8OBik-jJAH02N20HU2QByzoVISQaUqTJ6VCk1WTCs2ucq91KWYcwL_2BElZuJt1ubI20y8p_PCuxSePX3PY9kRcBG8PwhsdrbzyQaH-a9OESUYm3Sf9joov79FSCY7hOAKtVSgmzbi872c_2fhOgxYbv0FO8jrOKZQ2BpqMjPEfJumcxrOAo2KpfzJ_wBZ6-Sj</recordid><startdate>20140116</startdate><enddate>20140116</enddate><creator>DiBenedictis, Brett T</creator><creator>Helfand, Alexander I</creator><creator>Baum, Michael J</creator><creator>Cherry, James A</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20140116</creationdate><title>A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice</title><author>DiBenedictis, Brett T ; Helfand, Alexander I ; Baum, Michael J ; Cherry, James A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-4c23fc036e4b6eca1938c4fd209949f4130d9b381042c6f5198d31f0dfbe257b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amygdala - anatomy & histology</topic><topic>Amygdala - metabolism</topic><topic>Animals</topic><topic>Anterograde tracing</topic><topic>Axon terminal</topic><topic>Biological and medical sciences</topic><topic>Dextrans - metabolism</topic><topic>Efferent Pathways - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Medial amygdala</topic><topic>Mice</topic><topic>Neurology</topic><topic>Olfactory</topic><topic>Olfactory Pathways - cytology</topic><topic>Olfactory Pathways - physiology</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Prosencephalon - cytology</topic><topic>Prosencephalon - physiology</topic><topic>Rhodamines - metabolism</topic><topic>Septal Nuclei - cytology</topic><topic>Sociosexual behavior</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiBenedictis, Brett T</creatorcontrib><creatorcontrib>Helfand, Alexander I</creatorcontrib><creatorcontrib>Baum, Michael J</creatorcontrib><creatorcontrib>Cherry, James A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiBenedictis, Brett T</au><au>Helfand, Alexander I</au><au>Baum, Michael J</au><au>Cherry, James A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2014-01-16</date><risdate>2014</risdate><volume>1543</volume><spage>101</spage><epage>108</epage><pages>101-108</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract In rodents, many aspects of sociosexual behavior are mediated by chemosignals released by opposite-sex conspecifics. 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We found that the MeP more densely innervates the medial and intermediate regions of the posterior bed nucleus of the stria terminalis (pBNST) and the posteromedial cortical amygdala (PMCo), while the MeA more densely innervates the horizontal diagonal band of Broca (HDB) and the medial olfactory tubercle (mOT), a region that may be a component of the circuitry responsible for olfactory-mediated motivated behaviors.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>24262912</pmid><doi>10.1016/j.brainres.2013.10.046</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala - anatomy & histology Amygdala - metabolism Animals Anterograde tracing Axon terminal Biological and medical sciences Dextrans - metabolism Efferent Pathways - physiology Female Fundamental and applied biological sciences. Psychology Medial amygdala Mice Neurology Olfactory Olfactory Pathways - cytology Olfactory Pathways - physiology Olfactory system and olfaction. Gustatory system and gustation Prosencephalon - cytology Prosencephalon - physiology Rhodamines - metabolism Septal Nuclei - cytology Sociosexual behavior Vertebrates: nervous system and sense organs |
| title | A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice |
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