Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction

Arsenic exposure through drinking water is a serious global health issue. Observational studies suggest that individuals who metabolize arsenic efficiently are at lower risk for toxicities such as arsenical skin lesions. Using two single nucleotide polymorphisms(SNPs) in the 10q24.32 region (near AS...

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Veröffentlicht in:	International journal of epidemiology 2013-12, Vol.42 (6), p.1862-1872
Hauptverfasser:	PIERCE, Brandon L, LIN TONG, AHMED, Alauddin, QUASEM, Iftekhar, HORE, Samar K, ALAM, Shafiul, ISLAM, Tariqul, HARJES, Judith, SARWAR, Golam, SLAVKOVICH, Vesna, GAMBLE, Mary V, YU CHEN, ARGOS, Maria, YUNUS, Mohammad, RAHMAN, Mahfuzar, BARON, John A, GRAZIANO, Joseph H, AHSAN, Habibul, JIANJUN GAO, JASMINE, Farzana, ROY, Shantanu, PAUL-BRUTUS, Rachelle, RAHAMAN, Ronald, RAKIBUZ-ZAMAN, Muhammad, PARVEZ, Faruque
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Arsenic Poisoning - complications Arsenic Poisoning - epidemiology Arsenic Poisoning - genetics Arsenicals - metabolism Arsenicals - urine Bangladesh - epidemiology Biological and medical sciences Cacodylic Acid - urine Causality Cohort Studies Environment. Living conditions Environmental Exposure - statistics & numerical data Female Gene-Environment Interaction Genetic Predisposition to Disease Genotype Humans Male Medical sciences Mendelian Randomization Analysis Methyltransferases - genetics Middle Aged Miscellaneous Odds Ratio Polymorphism, Single Nucleotide Public health. Hygiene Public health. Hygiene-occupational medicine Skin Diseases - epidemiology Skin Diseases - etiology Skin Diseases - genetics Young Adult
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