TMPRSS2:ERG Gene Fusion Predicts Subsequent Detection of Prostate Cancer in Patients With High-Grade Prostatic Intraepithelial Neoplasia

High-grade prostatic intraepithelial neoplasia (HGPIN) is considered a precursor lesion of prostate cancer (PCa). The predictive value of ERG gene fusion in HGPIN for PCa was interrogated as a post hoc analysis in the context of a randomized clinical trial. The GTx Protocol G300104 randomly assigned...

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Veröffentlicht in:	Journal of clinical oncology 2014-01, Vol.32 (3), p.206-211
Hauptverfasser:	Park, Kyung, Dalton, James T, Narayanan, Ramesh, Barbieri, Christopher E, Hancock, Michael L, Bostwick, David G, Steiner, Mitchell S, Rubin, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Biomarkers, Tumor - genetics Biopsy Disease Progression Gene Expression Regulation, Neoplastic Gene Fusion Humans Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Grading Nephrology. Urinary tract diseases Oncogene Proteins, Fusion - genetics ORIGINAL REPORTS Prostatic Intraepithelial Neoplasia - diagnosis Prostatic Intraepithelial Neoplasia - genetics Prostatic Intraepithelial Neoplasia - metabolism Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Toremifene - therapeutic use Tumors Tumors of the urinary system Up-Regulation Urinary tract. Prostate gland
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