Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

•The structure of CTNNBL1 includes an abbreviated armadillo domain.•CTNNBL1 is a novel NLS binding protein with a unique carboxy-terminal structure.•Structure-based mutagenesis of CTNNBL1 shows NLS binding distinct from karyopherins. CTNNBL1 is a spliceosome-associated protein that binds nuclear loc...

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Veröffentlicht in:	FEBS letters 2014-01, Vol.588 (1), p.21-27
Hauptverfasser:	Ganesh, Karuna, van Maldegem, Febe, Telerman, Stephanie B., Simpson, Paul, Johnson, Christopher M., Williams, Roger L., Neuberger, Michael S., Rada, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Karyopherins - chemistry alpha Karyopherins - genetics alpha Karyopherins - metabolism Amino Acid Sequence antibodies Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Armadillo domain Armadillo Domain Proteins - chemistry Armadillo Domain Proteins - genetics Armadillo Domain Proteins - metabolism Binding Sites - genetics crystal structure Crystallography, X-Ray DNA Mutational Analysis Electrophoresis, Polyacrylamide Gel HEK293 Cells Humans karyopherins Models, Molecular Molecular Sequence Data Mutation Nuclear import nuclear localization signals Nuclear Localization Signals - chemistry Nuclear Localization Signals - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Structure, Secondary Protein Structure, Tertiary protein transport Sequence Homology, Amino Acid Splicing
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