Monoamine Oxidase and Cerebral Uptake of Dopaminergic Drugs

The brain uptake of amines that do not enter the brain or enter it poorly was promoted by non-competitive inhibitors of monoamine oxidase, as shown by behavioral and chemical criteria. Mice pretreated with water or enzyme inhibitors other than those mentioned were placid after receiving dopamine (3,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1974-07, Vol.71 (7), p.2715-2719
Hauptverfasser:	Cotzias, George C., Tang, Lily C., Ginos, James Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animals Apomorphine - pharmacology Aporphines Aporphines - metabolism Aporphines - pharmacology Behavior, Animal - drug effects Biological Sciences: Medical Sciences Brain - metabolism Catecholamines Catechols Dihydroxyphenylalanine - pharmacology Dopamine - metabolism Dopamine - pharmacology Dosage Enzymes Epinephrine - pharmacology Iproniazid - pharmacology Male Methylene Blue Mice Monoamine Oxidase - physiology Monoamine oxidase inhibitors Monoamine Oxidase Inhibitors - pharmacology Motor Activity - drug effects Nialamide - pharmacology Norepinephrine Norepinephrine - pharmacology Oxidases Oxotremorine - pharmacology Staining and Labeling
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