AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Despite the use of 5-fluorouracil (5-FU)-based adjuvant treatments, a large proportion of patients with high-risk stage II/III colorectal cancer will relapse. Thus, novel therapeutic strategies are needed for early-stage colorectal cancer. Residual micrometastatic disease from the primary tumor is a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2014-01, Vol.20 (1), p.164-175
Hauptverfasser:	DUNNE, Philip D, MCART, Darragh G, REDMOND, Keara, LONGLEY, Daniel B, SALTO-TELLEZ, Manuel, JOHNSTON, Patrick G, VAN SCHAEYBROECK, Sandra, BLAYNEY, Jaine K, KALIMUTHO, Murugan, GREER, Samanda, TINGTING WANG, SRIVASTAVA, Supriya, CHEE WEE ONG, ARTHUR, Ken, LOUGHREY, Maurice
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Aged Antineoplastic agents Antineoplastic Agents - pharmacology Axl Receptor Tyrosine Kinase Biological and medical sciences Biomarkers, Tumor - physiology Cell Line, Tumor Cell Movement - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease Progression Female Fluorouracil - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Multivariate Analysis Neoplasm Invasiveness Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - prevention & control Neoplasm Staging Organoplatinum Compounds - pharmacology Oxaliplatin Pharmacology. Drug treatments Prognosis Proportional Hazards Models Proto-Oncogene Proteins - physiology Receptor Protein-Tyrosine Kinases - physiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!