Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro
Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experi...
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| creator | Liu, Hong-Xu Shang, Juju Chu, Fuyong Li, Aiyong Wu, Bao Xie, Xinran Liu, Weihong Yang, Hongzhi Tong, Tong |
| description | Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining. The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay. Results. Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury. Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis. The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning. These effects of SYD were inhibited by LY294002. Conclusions. The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway. |
| doi_str_mv | 10.1155/2013/956397 |
| format | Article |
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The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining. The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay. Results. Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury. Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis. The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning. These effects of SYD were inhibited by LY294002. Conclusions. The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/956397</identifier><identifier>PMID: 24454518</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Angioplasty ; Animal models ; Apoptosis ; BAX protein ; Bcl-2 protein ; Cardiomyocytes ; Chinese medicine ; Coronary vessels ; Creatine ; Creatine kinase ; Herbal medicine ; Histopathology ; Hypertension ; Immunocytochemistry ; Ischemia ; Kinases ; Laboratories ; Malondialdehyde ; Medical research ; Myocardial ischemia ; Myocardium ; Reperfusion ; Rodents ; Staining ; Superoxide dismutase ; Traditional Chinese medicine ; Veins & arteries ; Viability</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-11</ispartof><rights>Copyright © 2013 Hongxu Liu et al.</rights><rights>Copyright © 2013 Hongxu Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Hongxu Liu et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c9783ea1aebb0194056616b4ec1f53e516f60b4ce8089734bca2befa8c0cdddf3</citedby><cites>FETCH-LOGICAL-c429t-c9783ea1aebb0194056616b4ec1f53e516f60b4ce8089734bca2befa8c0cdddf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885196/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885196/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24454518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Xiong, Xingjiang</contributor><contributor>Xingjiang Xiong</contributor><creatorcontrib>Liu, Hong-Xu</creatorcontrib><creatorcontrib>Shang, Juju</creatorcontrib><creatorcontrib>Chu, Fuyong</creatorcontrib><creatorcontrib>Li, Aiyong</creatorcontrib><creatorcontrib>Wu, Bao</creatorcontrib><creatorcontrib>Xie, Xinran</creatorcontrib><creatorcontrib>Liu, Weihong</creatorcontrib><creatorcontrib>Yang, Hongzhi</creatorcontrib><creatorcontrib>Tong, Tong</creatorcontrib><title>Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining. The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay. Results. Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury. Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis. The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning. These effects of SYD were inhibited by LY294002. Conclusions. The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Angioplasty</subject><subject>Animal models</subject><subject>Apoptosis</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>Cardiomyocytes</subject><subject>Chinese medicine</subject><subject>Coronary vessels</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Herbal medicine</subject><subject>Histopathology</subject><subject>Hypertension</subject><subject>Immunocytochemistry</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Malondialdehyde</subject><subject>Medical research</subject><subject>Myocardial ischemia</subject><subject>Myocardium</subject><subject>Reperfusion</subject><subject>Rodents</subject><subject>Staining</subject><subject>Superoxide dismutase</subject><subject>Traditional Chinese medicine</subject><subject>Veins & 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Hong-Xu</creator><creator>Shang, Juju</creator><creator>Chu, Fuyong</creator><creator>Li, Aiyong</creator><creator>Wu, Bao</creator><creator>Xie, Xinran</creator><creator>Liu, Weihong</creator><creator>Yang, Hongzhi</creator><creator>Tong, Tong</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi 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Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro</title><author>Liu, Hong-Xu ; Shang, Juju ; Chu, Fuyong ; Li, Aiyong ; Wu, Bao ; Xie, Xinran ; Liu, Weihong ; Yang, Hongzhi ; Tong, Tong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c9783ea1aebb0194056616b4ec1f53e516f60b4ce8089734bca2befa8c0cdddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Angioplasty</topic><topic>Animal models</topic><topic>Apoptosis</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>Cardiomyocytes</topic><topic>Chinese medicine</topic><topic>Coronary vessels</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Herbal medicine</topic><topic>Histopathology</topic><topic>Hypertension</topic><topic>Immunocytochemistry</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Malondialdehyde</topic><topic>Medical research</topic><topic>Myocardial ischemia</topic><topic>Myocardium</topic><topic>Reperfusion</topic><topic>Rodents</topic><topic>Staining</topic><topic>Superoxide dismutase</topic><topic>Traditional Chinese medicine</topic><topic>Veins & arteries</topic><topic>Viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hong-Xu</creatorcontrib><creatorcontrib>Shang, Juju</creatorcontrib><creatorcontrib>Chu, Fuyong</creatorcontrib><creatorcontrib>Li, Aiyong</creatorcontrib><creatorcontrib>Wu, Bao</creatorcontrib><creatorcontrib>Xie, Xinran</creatorcontrib><creatorcontrib>Liu, Weihong</creatorcontrib><creatorcontrib>Yang, Hongzhi</creatorcontrib><creatorcontrib>Tong, Tong</creatorcontrib><collection>الدوريات العلمية 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Xingjiang</au><au>Xingjiang Xiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining. The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay. Results. Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury. Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis. The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning. These effects of SYD were inhibited by LY294002. Conclusions. The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24454518</pmid><doi>10.1155/2013/956397</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Angioplasty Animal models Apoptosis BAX protein Bcl-2 protein Cardiomyocytes Chinese medicine Coronary vessels Creatine Creatine kinase Herbal medicine Histopathology Hypertension Immunocytochemistry Ischemia Kinases Laboratories Malondialdehyde Medical research Myocardial ischemia Myocardium Reperfusion Rodents Staining Superoxide dismutase Traditional Chinese medicine Veins & arteries Viability |
| title | Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro |
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