Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
We have previously shown that miR-486-5p is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of miR-486-5p in the progression and metastasis of non-small-cell lung cancer (NSCLC). We evaluated miR-486-5p expression status on 76 frozen an...
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| Veröffentlicht in: | Oncogene 2014-02, Vol.33 (9), p.1181-1189 |
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| creator | Wang, J Tian, X Han, R Zhang, X Wang, X Shen, H Xue, L Liu, Y Yan, X Shen, J Mannoor, K Deepak, J Donahue, J M Stass, S A Xing, L Jiang, F |
| description | We have previously shown that
miR-486-5p
is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of
miR-486-5p
in the progression and metastasis of non-small-cell lung cancer (NSCLC). We evaluated
miR-486-5p
expression status on 76 frozen and 33 formalin-fixed paraffin-embedded tissues of NSCLC by quantitative reverse transcriptase PCR to determine its clinicopathologic significance. We then performed function analysis of
miR-486-5p
to determine its potential roles on cancer cell migration and invasion
in vitro
and metastasis
in vivo
. We also investigated the target genes of
miR-486-5p
in lung tumorigenesis.
miR-486-5p
expression level was significantly lower in lung tumors compared with their corresponding normal tissues (
P |
| doi_str_mv | 10.1038/onc.2013.42 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3883922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A362965436</galeid><sourcerecordid>A362965436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c640t-eb3e77975d976af0bcd2cf719ec40b6f911dd5f7e51433782c337903affaa69d3</originalsourceid><addsrcrecordid>eNp9ks9rFDEUx4Modl09eZeAF6HOmt8zuRSWVluhoBQ9h0wmGVNmkjWZUXryXzfj1rKVIgkJ5H3eN_m-PABeYrTBiDbvYjAbgjDdMPIIrDCrRcW5ZI_BCkmOKkkoOQLPcr5GCNUSkafgiFBWFw6vwK-z-DMk28-DnnwMMDo4-quKNUVkB00MU_LtPNkMpwineYwJ7lLsk815wXXo4Ggnncv0GbY3cNKpt5MP_cL9SfC9Dd7A7dXF-fYzhz7AYS5ho4Ox6Tl44vSQ7YvbfQ2-fnj_5fSiuvx0_vF0e1kZwdBU2ZbaupY172QttEOt6YhxNZbWMNQKJzHuOu5qyzGjtG6IKatEVDuntZAdXYOTve5ubkfbGVuM6UHtkh91ulFRe3U_Evw31ccfijYNlYQUgTe3Ail-n22e1OizscOgg41zVphT1hDGC74Gr_9Br-OcQrGniGAFxALL_1GYIyJww8QB1evBKh9cLK8zy9VqSwWRgjMqCrV5gCqjs6Mvn2idL-f3Eo73CSbFnJN1d5XASC1dpUpXqaWrFFu8vzos3h37t40K8HYP5BIKvU0HXh7Q-w05cNZ2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1502618469</pqid></control><display><type>article</type><title>Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Wang, J ; Tian, X ; Han, R ; Zhang, X ; Wang, X ; Shen, H ; Xue, L ; Liu, Y ; Yan, X ; Shen, J ; Mannoor, K ; Deepak, J ; Donahue, J M ; Stass, S A ; Xing, L ; Jiang, F</creator><creatorcontrib>Wang, J ; Tian, X ; Han, R ; Zhang, X ; Wang, X ; Shen, H ; Xue, L ; Liu, Y ; Yan, X ; Shen, J ; Mannoor, K ; Deepak, J ; Donahue, J M ; Stass, S A ; Xing, L ; Jiang, F</creatorcontrib><description>We have previously shown that
miR-486-5p
is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of
miR-486-5p
in the progression and metastasis of non-small-cell lung cancer (NSCLC). We evaluated
miR-486-5p
expression status on 76 frozen and 33 formalin-fixed paraffin-embedded tissues of NSCLC by quantitative reverse transcriptase PCR to determine its clinicopathologic significance. We then performed function analysis of
miR-486-5p
to determine its potential roles on cancer cell migration and invasion
in vitro
and metastasis
in vivo
. We also investigated the target genes of
miR-486-5p
in lung tumorigenesis.
miR-486-5p
expression level was significantly lower in lung tumors compared with their corresponding normal tissues (
P
<0.0001), and associated with stage (
P
=0.0001) and lymph node metastasis of NSCLC (
P
=0.0019). Forced expression of
miR-486-5p
inhibited NSCLC cell migration and invasion
in vitro
and metastasis in mice by inhibiting cell proliferation. Furthermore, ectopic expression of
miR-486-5p
in cancer cells reduced
ARHGAP5
expression level, whereas
miR-486-5p
silencing increased its expression. Luciferase assay demonstrated that
miR-486-5p
could directly bind to the 3′-untranslated region of
ARHGAP5
. The expression level of
miR-486-5p
was inversely correlated with that of
ARHGAP5
in lung tumor tissues (
P
=0.0156). Reduced expression of
ARHGAP5
considerably inhibited lung cancer cell migration and invasion, resembling that of
miR-486-5p
overexpression.
miR-486-5p
may act as a tumor-suppressor contributing to the progression and metastasis of NSCLC by targeting
ARHGAP5
.
miR-486-5p
would provide potential diagnostic and therapeutic targets for the disease.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2013.42</identifier><identifier>PMID: 23474761</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3' Untranslated regions ; 3' Untranslated Regions - genetics ; 631/337/384/331 ; 631/67/1059/602 ; 692/699/67/1612/1350 ; 692/699/67/395 ; Apoptosis ; Cancer ; Carcinogenesis ; Carcinogenesis - genetics ; Carcinogenesis - pathology ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell adhesion & migration ; Cell Biology ; Cell Line, Tumor ; Cell migration ; Cell Movement - genetics ; Cell Proliferation ; Chromosome 5 ; Complications and side effects ; Development and progression ; Disease Progression ; Down-Regulation - genetics ; Ectopic expression ; Gene therapy ; GTPase-Activating Proteins - genetics ; Human Genetics ; Humans ; Internal Medicine ; Kinases ; Lung cancer ; Lung cancer, Non-small cell ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Lymph nodes ; Lymphatic Metastasis - genetics ; Lymphatic Metastasis - pathology ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Non-small cell lung carcinoma ; Oncology ; Oncology, Experimental ; original-article ; Paraffin ; Physiological aspects ; RNA-directed DNA polymerase ; Small cell lung carcinoma ; Therapeutic targets ; Tumor suppressor genes ; Tumorigenesis ; Tumors ; Up-Regulation - genetics</subject><ispartof>Oncogene, 2014-02, Vol.33 (9), p.1181-1189</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 27, 2014</rights><rights>Macmillan Publishers Limited 2014.</rights><rights>2013 Macmillan Publishers Limited All rights reserved 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c640t-eb3e77975d976af0bcd2cf719ec40b6f911dd5f7e51433782c337903affaa69d3</citedby><cites>FETCH-LOGICAL-c640t-eb3e77975d976af0bcd2cf719ec40b6f911dd5f7e51433782c337903affaa69d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/onc.2013.42$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/onc.2013.42$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23474761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J</creatorcontrib><creatorcontrib>Tian, X</creatorcontrib><creatorcontrib>Han, R</creatorcontrib><creatorcontrib>Zhang, X</creatorcontrib><creatorcontrib>Wang, X</creatorcontrib><creatorcontrib>Shen, H</creatorcontrib><creatorcontrib>Xue, L</creatorcontrib><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>Yan, X</creatorcontrib><creatorcontrib>Shen, J</creatorcontrib><creatorcontrib>Mannoor, K</creatorcontrib><creatorcontrib>Deepak, J</creatorcontrib><creatorcontrib>Donahue, J M</creatorcontrib><creatorcontrib>Stass, S A</creatorcontrib><creatorcontrib>Xing, L</creatorcontrib><creatorcontrib>Jiang, F</creatorcontrib><title>Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>We have previously shown that
miR-486-5p
is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of
miR-486-5p
in the progression and metastasis of non-small-cell lung cancer (NSCLC). We evaluated
miR-486-5p
expression status on 76 frozen and 33 formalin-fixed paraffin-embedded tissues of NSCLC by quantitative reverse transcriptase PCR to determine its clinicopathologic significance. We then performed function analysis of
miR-486-5p
to determine its potential roles on cancer cell migration and invasion
in vitro
and metastasis
in vivo
. We also investigated the target genes of
miR-486-5p
in lung tumorigenesis.
miR-486-5p
expression level was significantly lower in lung tumors compared with their corresponding normal tissues (
P
<0.0001), and associated with stage (
P
=0.0001) and lymph node metastasis of NSCLC (
P
=0.0019). Forced expression of
miR-486-5p
inhibited NSCLC cell migration and invasion
in vitro
and metastasis in mice by inhibiting cell proliferation. Furthermore, ectopic expression of
miR-486-5p
in cancer cells reduced
ARHGAP5
expression level, whereas
miR-486-5p
silencing increased its expression. Luciferase assay demonstrated that
miR-486-5p
could directly bind to the 3′-untranslated region of
ARHGAP5
. The expression level of
miR-486-5p
was inversely correlated with that of
ARHGAP5
in lung tumor tissues (
P
=0.0156). Reduced expression of
ARHGAP5
considerably inhibited lung cancer cell migration and invasion, resembling that of
miR-486-5p
overexpression.
miR-486-5p
may act as a tumor-suppressor contributing to the progression and metastasis of NSCLC by targeting
ARHGAP5
.
miR-486-5p
would provide potential diagnostic and therapeutic targets for the disease.</description><subject>3' Untranslated regions</subject><subject>3' Untranslated Regions - genetics</subject><subject>631/337/384/331</subject><subject>631/67/1059/602</subject><subject>692/699/67/1612/1350</subject><subject>692/699/67/395</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Chromosome 5</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Down-Regulation - genetics</subject><subject>Ectopic expression</subject><subject>Gene therapy</subject><subject>GTPase-Activating Proteins - genetics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Lung cancer, Non-small cell</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - genetics</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>original-article</subject><subject>Paraffin</subject><subject>Physiological aspects</subject><subject>RNA-directed DNA polymerase</subject><subject>Small cell lung carcinoma</subject><subject>Therapeutic targets</subject><subject>Tumor suppressor genes</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Up-Regulation - 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of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer</title><author>Wang, J ; Tian, X ; Han, R ; Zhang, X ; Wang, X ; Shen, H ; Xue, L ; Liu, Y ; Yan, X ; Shen, J ; Mannoor, K ; Deepak, J ; Donahue, J M ; Stass, S A ; Xing, L ; Jiang, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c640t-eb3e77975d976af0bcd2cf719ec40b6f911dd5f7e51433782c337903affaa69d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>3' Untranslated regions</topic><topic>3' Untranslated Regions - genetics</topic><topic>631/337/384/331</topic><topic>631/67/1059/602</topic><topic>692/699/67/1612/1350</topic><topic>692/699/67/395</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell adhesion & migration</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Chromosome 5</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Down-Regulation - genetics</topic><topic>Ectopic expression</topic><topic>Gene therapy</topic><topic>GTPase-Activating Proteins - genetics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Lung cancer, Non-small cell</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis - genetics</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Non-small cell lung carcinoma</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>original-article</topic><topic>Paraffin</topic><topic>Physiological aspects</topic><topic>RNA-directed DNA polymerase</topic><topic>Small cell lung carcinoma</topic><topic>Therapeutic targets</topic><topic>Tumor suppressor genes</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Up-Regulation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J</creatorcontrib><creatorcontrib>Tian, X</creatorcontrib><creatorcontrib>Han, R</creatorcontrib><creatorcontrib>Zhang, X</creatorcontrib><creatorcontrib>Wang, X</creatorcontrib><creatorcontrib>Shen, H</creatorcontrib><creatorcontrib>Xue, L</creatorcontrib><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>Yan, X</creatorcontrib><creatorcontrib>Shen, J</creatorcontrib><creatorcontrib>Mannoor, K</creatorcontrib><creatorcontrib>Deepak, J</creatorcontrib><creatorcontrib>Donahue, J M</creatorcontrib><creatorcontrib>Stass, S A</creatorcontrib><creatorcontrib>Xing, L</creatorcontrib><creatorcontrib>Jiang, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni 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Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J</au><au>Tian, X</au><au>Han, R</au><au>Zhang, X</au><au>Wang, X</au><au>Shen, H</au><au>Xue, L</au><au>Liu, Y</au><au>Yan, X</au><au>Shen, J</au><au>Mannoor, K</au><au>Deepak, J</au><au>Donahue, J M</au><au>Stass, S A</au><au>Xing, L</au><au>Jiang, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2014-02-27</date><risdate>2014</risdate><volume>33</volume><issue>9</issue><spage>1181</spage><epage>1189</epage><pages>1181-1189</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>We have previously shown that
miR-486-5p
is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of
miR-486-5p
in the progression and metastasis of non-small-cell lung cancer (NSCLC). We evaluated
miR-486-5p
expression status on 76 frozen and 33 formalin-fixed paraffin-embedded tissues of NSCLC by quantitative reverse transcriptase PCR to determine its clinicopathologic significance. We then performed function analysis of
miR-486-5p
to determine its potential roles on cancer cell migration and invasion
in vitro
and metastasis
in vivo
. We also investigated the target genes of
miR-486-5p
in lung tumorigenesis.
miR-486-5p
expression level was significantly lower in lung tumors compared with their corresponding normal tissues (
P
<0.0001), and associated with stage (
P
=0.0001) and lymph node metastasis of NSCLC (
P
=0.0019). Forced expression of
miR-486-5p
inhibited NSCLC cell migration and invasion
in vitro
and metastasis in mice by inhibiting cell proliferation. Furthermore, ectopic expression of
miR-486-5p
in cancer cells reduced
ARHGAP5
expression level, whereas
miR-486-5p
silencing increased its expression. Luciferase assay demonstrated that
miR-486-5p
could directly bind to the 3′-untranslated region of
ARHGAP5
. The expression level of
miR-486-5p
was inversely correlated with that of
ARHGAP5
in lung tumor tissues (
P
=0.0156). Reduced expression of
ARHGAP5
considerably inhibited lung cancer cell migration and invasion, resembling that of
miR-486-5p
overexpression.
miR-486-5p
may act as a tumor-suppressor contributing to the progression and metastasis of NSCLC by targeting
ARHGAP5
.
miR-486-5p
would provide potential diagnostic and therapeutic targets for the disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23474761</pmid><doi>10.1038/onc.2013.42</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 2014-02, Vol.33 (9), p.1181-1189 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3883922 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 3' Untranslated regions 3' Untranslated Regions - genetics 631/337/384/331 631/67/1059/602 692/699/67/1612/1350 692/699/67/395 Apoptosis Cancer Carcinogenesis Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation Chromosome 5 Complications and side effects Development and progression Disease Progression Down-Regulation - genetics Ectopic expression Gene therapy GTPase-Activating Proteins - genetics Human Genetics Humans Internal Medicine Kinases Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - pathology Lymph nodes Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Medicine Medicine & Public Health Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Non-small cell lung carcinoma Oncology Oncology, Experimental original-article Paraffin Physiological aspects RNA-directed DNA polymerase Small cell lung carcinoma Therapeutic targets Tumor suppressor genes Tumorigenesis Tumors Up-Regulation - genetics |
| title | Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A44%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Downregulation%20of%20miR-486-5p%20contributes%20to%20tumor%20progression%20and%20metastasis%20by%20targeting%20protumorigenic%20ARHGAP5%20in%20lung%20cancer&rft.jtitle=Oncogene&rft.au=Wang,%20J&rft.date=2014-02-27&rft.volume=33&rft.issue=9&rft.spage=1181&rft.epage=1189&rft.pages=1181-1189&rft.issn=0950-9232&rft.eissn=1476-5594&rft.coden=ONCNES&rft_id=info:doi/10.1038/onc.2013.42&rft_dat=%3Cgale_pubme%3EA362965436%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1502618469&rft_id=info:pmid/23474761&rft_galeid=A362965436&rfr_iscdi=true |