CYP2B66 is associated with increased breast cancer risk

The cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of testosterone. Functional changes in this enzyme may influence endogenous hormone exposure, which has been associated with risk of breast cancer. To assess potential associations between two functional polymorphisms CYP2B6_516_G>T (...

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Veröffentlicht in:	International journal of cancer 2014-01, Vol.134 (2), p.426-430
Hauptverfasser:	Justenhoven, Christina, Pentimalli, Daniela, Rabstein, Sylvia, Harth, Volker, Lotz, Anne, Pesch, Beate, Brüning, Thomas, Dörk, Thilo, Schürmann, Peter, Bogdanova, Natalia, Park‐Simon, Tjoung‐Won, Couch, Fergus J., Olson, Janet E., Fasching, Peter A., Beckmann, Matthias W., Häberle, Lothar, Ekici, Arif, Hall, Per, Czene, Kamilla, Liu, Janjun, Li, Jingmei, Baisch, Christian, Hamann, Ute, Ko, Yon‐Dschun, Brauch, Hiltrud
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Biomarkers, Tumor - genetics Breast cancer breast cancer risk Breast Neoplasms - etiology Cancer Case-Control Studies CYP2B6 Cytochrome P-450 CYP2B6 Enzymes Female Follow-Up Studies Genetic Predisposition to Disease Genotype Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical research Medical sciences Meta-Analysis as Topic Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) polymorphism Polymorphism, Genetic - genetics Prognosis Risk Factors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization testosterone Tumors Women
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