Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors

Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks GB, Belousova EG, Xuan W, Bye PT; the National Hyperto...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2013-12, Vol.305 (11), p.C1114-C1122
Hauptverfasser:	Rasgado-Flores, Hector, Krishna Mandava, Vamsi, Siman, Homayoun, Van Driessche, Willy, Pilewski, Joseph M, Randell, Scott H, Bridges, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Amiloride - administration & dosage Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Cell Culture Techniques - methods Cells Cells, Cultured Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - metabolism Humans Ion Transport - drug effects Ion Transport - physiology Lungs Osmosis Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Saline Solution, Hypertonic - administration & dosage Sodium - metabolism Thin films
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