The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer

Background and Objectives MUC1 is over‐expressed and aberrantly glycosylated in >60% of human pancreatic cancer (PC). Development of novel approaches for detection and/or targeting of MUC1 are critically needed and should be able to detect MUC1 on PC cells (including cancer stem cells) and in ser...

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Veröffentlicht in:	Journal of surgical oncology 2013-06, Vol.107 (7), p.713-722
Hauptverfasser:	Curry, Jennifer M., Thompson, Kyle J., Rao, Shanti G., Besmer, Dahlia M., Murphy, Andrea M., Grdzelishvili, Valery Z., Ahrens, William A., McKillop, Iain H., Sindram, David, Iannitti, David A., Martinie, John B., Mukherjee, Pinku
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Animals Antibodies, Monoclonal - pharmacology Antigens, CD - immunology Blotting, Western cancer stem cells Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Glycoproteins - immunology Glycosylation Humans Immunoenzyme Techniques Immunohistochemistry Male Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Mice, Transgenic Middle Aged MUC1 Mucin-1 - immunology Mucin-1 - isolation & purification Neoplasm Staging Neoplastic Stem Cells - immunology Pancreatic cancer Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Peptides - immunology Sensitivity and Specificity TAB 004 Up-Regulation
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