Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation

Aim. The aim of the present study was to investigate the effect of cornel iridoid glycoside (CIG) on tau hyperphosphorylation induced by wortmannin (WT) and GF-109203X (GFX) and the underlying mechanisms. Methods. Human neuroblastoma SK-N-SH cells were preincubated with CIG (50, 100, and 200 µg/ml,...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-9
Hauptverfasser:	Kuai, Xue-xian, Zhang, Li, Yang, Cui-cui, Zhang, Lan, Li, Lin, Yu, Jian-chun, Li, Ya-li
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alzheimer's disease Apoptosis Brain research Care and treatment Cytoskeleton Demethylation Glycogen Glycogen synthase kinase 3 Glycosides Immunoglobulins Immunohistochemistry Kinases Medical research Medicine, Experimental Metabolic diseases Neuroblastoma Neurochemistry Neurodegeneration Phosphatase Phosphoprotein phosphatase Phosphorylation Protein phosphatase Proteins Tau protein Western blotting Wortmannin
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