Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

HIV-1 entry into CD4+ T cells requires binding of the virus to CD4 followed by engagement of either the C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4) coreceptor. Pharmacologic blockade or genetic inactivation of either coreceptor protects cells from infection by viruses that...

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Veröffentlicht in:	Blood 2014-01, Vol.123 (1), p.61-69
Hauptverfasser:	Didigu, Chuka A., Wilen, Craig B., Wang, Jianbin, Duong, Jennifer, Secreto, Anthony J., Danet-Desnoyers, Gwenn A., Riley, James L., Gregory, Phillip D., June, Carl H., Holmes, Michael C., Doms, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - virology Cell Proliferation Endodeoxyribonucleases - metabolism Female HEK293 Cells HIV Infections - immunology HIV Infections - prevention & control HIV Infections - therapy HIV-1 Humans Immunobiology Male Mice Receptors, CCR5 - genetics Receptors, Chemokine - metabolism Receptors, CXCR4 - genetics Zinc Fingers
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