Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient
Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient. Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S. : Allograft rejection in HLA identi...
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| creator | Narayan, Shoba Tsai, Eileen W. Zhang, Qiuheng Wallace, William D. Reed, Elaine F. Ettenger, Robert B. |
| description | Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient.
Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S.
: Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients. |
| doi_str_mv | 10.1111/j.1399-3046.2010.01407.x |
| format | Article |
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Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S.
: Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/j.1399-3046.2010.01407.x</identifier><identifier>PMID: 21199204</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Alleles ; Antibodies ; antibody‐mediated rejection ; anti‐MICA antibody ; Biopsy ; Branchio-Oto-Renal Syndrome - immunology ; Branchio-Oto-Renal Syndrome - therapy ; Case reports ; Classification ; Donors ; donor‐specific anti‐MICA antibody ; Female ; Graft Rejection ; highly sensitized patient ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA Antigens - chemistry ; Humans ; Kidney transplantation ; Kidney Transplantation - methods ; Lymphocytes ; MICA protein ; non‐HLA antibody ; Pediatrics ; Pediatrics - methods ; Retinoblastoma protein ; Transplantation, Homologous ; Treatment Outcome</subject><ispartof>Pediatric transplantation, 2011-02, Vol.15 (1), p.E1-E7</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5067-194817b5ea6a0308b85622fbb66986a03efe5522f6d5284a4008d029d40108b83</citedby><cites>FETCH-LOGICAL-c5067-194817b5ea6a0308b85622fbb66986a03efe5522f6d5284a4008d029d40108b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3046.2010.01407.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3046.2010.01407.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21199204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narayan, Shoba</creatorcontrib><creatorcontrib>Tsai, Eileen W.</creatorcontrib><creatorcontrib>Zhang, Qiuheng</creatorcontrib><creatorcontrib>Wallace, William D.</creatorcontrib><creatorcontrib>Reed, Elaine F.</creatorcontrib><creatorcontrib>Ettenger, Robert B.</creatorcontrib><title>Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient.
Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S.
: Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients.</description><subject>Adolescent</subject><subject>Alleles</subject><subject>Antibodies</subject><subject>antibody‐mediated rejection</subject><subject>anti‐MICA antibody</subject><subject>Biopsy</subject><subject>Branchio-Oto-Renal Syndrome - immunology</subject><subject>Branchio-Oto-Renal Syndrome - therapy</subject><subject>Case reports</subject><subject>Classification</subject><subject>Donors</subject><subject>donor‐specific anti‐MICA antibody</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>highly sensitized patient</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Testing</subject><subject>HLA Antigens - chemistry</subject><subject>Humans</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - methods</subject><subject>Lymphocytes</subject><subject>MICA protein</subject><subject>non‐HLA antibody</subject><subject>Pediatrics</subject><subject>Pediatrics - methods</subject><subject>Retinoblastoma protein</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctu1DAUtRCIPuAXkHesMtiOk9gbpKoqD6moCJW15Tg3HY8ycbA9tMMK_oBv7JdwM20HWIE3vj4-51xfH0IoZwuO69VqwUuti5LJeiEYooxL1ixuHpHD_cXjXd0UJZfigByltGKM11LJp-RAcK61YPKQ_Dhxmww0wgpc9mGkNqXgvM3Q0Wufl7QLY4i333-mCZzvvaN2zB7PH96fnuzqNnRb6lFIl_5qOWxpgjH57L-hwwQdWkVURRjtQHO0Y5oGlCHg_ORhzM_Ik94OCZ7f78fk85uzy9N3xfnFW-xxXriK1U3BtVS8aSuwtWUlU62qaiH6tq1rrWYIeqgqROquEkpayZjqmNCdxP9BdnlMXt_5Tpt2DZ3D1tEOZop-bePWBOvN3zejX5qr8NWUqlFC12jw8t4ghi8bSNmsfXIw4DgQNslo1nCpVFP9k6lkVWqFUSBT3TFdDClF6Pfv4czMUZuVmRM1c6JmjtrsojY3KH3x5zx74UO2vwe-9gNs_9vYfDy7_DSX5S9fALxH</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Narayan, Shoba</creator><creator>Tsai, Eileen W.</creator><creator>Zhang, Qiuheng</creator><creator>Wallace, William D.</creator><creator>Reed, Elaine F.</creator><creator>Ettenger, Robert B.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201102</creationdate><title>Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient</title><author>Narayan, Shoba ; Tsai, Eileen W. ; Zhang, Qiuheng ; Wallace, William D. ; Reed, Elaine F. ; Ettenger, Robert B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5067-194817b5ea6a0308b85622fbb66986a03efe5522f6d5284a4008d029d40108b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Alleles</topic><topic>Antibodies</topic><topic>antibody‐mediated rejection</topic><topic>anti‐MICA antibody</topic><topic>Biopsy</topic><topic>Branchio-Oto-Renal Syndrome - immunology</topic><topic>Branchio-Oto-Renal Syndrome - therapy</topic><topic>Case reports</topic><topic>Classification</topic><topic>Donors</topic><topic>donor‐specific anti‐MICA antibody</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>highly sensitized patient</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Testing</topic><topic>HLA Antigens - chemistry</topic><topic>Humans</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - methods</topic><topic>Lymphocytes</topic><topic>MICA protein</topic><topic>non‐HLA antibody</topic><topic>Pediatrics</topic><topic>Pediatrics - methods</topic><topic>Retinoblastoma protein</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narayan, Shoba</creatorcontrib><creatorcontrib>Tsai, Eileen W.</creatorcontrib><creatorcontrib>Zhang, Qiuheng</creatorcontrib><creatorcontrib>Wallace, William D.</creatorcontrib><creatorcontrib>Reed, Elaine F.</creatorcontrib><creatorcontrib>Ettenger, Robert B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narayan, Shoba</au><au>Tsai, Eileen W.</au><au>Zhang, Qiuheng</au><au>Wallace, William D.</au><au>Reed, Elaine F.</au><au>Ettenger, Robert B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2011-02</date><risdate>2011</risdate><volume>15</volume><issue>1</issue><spage>E1</spage><epage>E7</epage><pages>E1-E7</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient.
Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S.
: Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21199204</pmid><doi>10.1111/j.1399-3046.2010.01407.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Alleles Antibodies antibody‐mediated rejection anti‐MICA antibody Biopsy Branchio-Oto-Renal Syndrome - immunology Branchio-Oto-Renal Syndrome - therapy Case reports Classification Donors donor‐specific anti‐MICA antibody Female Graft Rejection highly sensitized patient Histocompatibility antigen HLA Histocompatibility Testing HLA Antigens - chemistry Humans Kidney transplantation Kidney Transplantation - methods Lymphocytes MICA protein non‐HLA antibody Pediatrics Pediatrics - methods Retinoblastoma protein Transplantation, Homologous Treatment Outcome |
| title | Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient |
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