$A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia$

A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia

Summary Novel agents are needed for patients with refractory and relapsed acute lymphoblastic leukaemia (ALL). Combotox is a 1:1 mixture of two immunotoxins (ITs), prepared by coupling deglycosylated ricin A chain (dgRTA) to monoclonal antibodies directed against CD22 (RFB4‐dgRTA) and CD19 (HD37‐dgR...

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Veröffentlicht in:	British journal of haematology 2011-08, Vol.154 (4), p.471-476
Hauptverfasser:	Schindler, John, Gajavelli, Srikanth, Ravandi, Farhad, Shen, YuMin, Parekh, Samir, Braunchweig, Ira, Barta, Stefan, Ghetie, Victor, Vitetta, Ellen, Verma, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphatic leukemia Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antigens, CD19 - immunology Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use anti‐CD19 anti‐CD22 Biological and medical sciences Blast CD19 antigen CD22 antigen Clinical trials Combotox Data processing Dose-Response Relationship, Drug Female Hematologic and hematopoietic diseases Humans Immunotoxins Immunotoxins - administration & dosage Immunotoxins - adverse effects Immunotoxins - therapeutic use leukaemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Liver Male Medical sciences Middle Aged Monoclonal antibodies Pediatrics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Recurrence Remission Ricin Ricin - administration & dosage Ricin - adverse effects Ricin - therapeutic use Sialic Acid Binding Ig-like Lectin 2 - immunology stem cell transplantation Toxicity Treatment Outcome vascular leak syndrome Young Adult
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