Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence

Addiction to nicotine and the ability to quit smoking are influenced by genetic factors. We used functional genomic approaches (chromatin immunoprecipitation (ChIP) and whole-genome sequencing) to identify cAMP response element-binding protein (CREB) targets following chronic nicotine administration...

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Veröffentlicht in:	Molecular psychiatry 2014-07, Vol.19 (7), p.801-810
Hauptverfasser:	Turner, J R, Ray, R, Lee, B, Everett, L, Xiang, J, Jepson, C, Kaestner, K H, Lerman, C, Blendy, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/649 631/378/1689/1300 631/80/86 692/700/565/1436 Addiction Addictions Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Aged Animals Behavior, Animal - drug effects Behavioral Sciences Biological and medical sciences Biological Psychology Chromatin Cigarette smoking Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Desintoxication. Drug withdrawal DNA - metabolism Drug addiction Drug dependence Drug withdrawal Epidermal growth factor ErbB-2 protein European Continental Ancestry Group - genetics Female Gene expression Genetic aspects Genetic engineering Genetic factors Genetic Predisposition to Disease - genetics Genetic research Genome-Wide Association Study Haplotypes Hippocampus - drug effects Hippocampus - metabolism Humans Immunoprecipitation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Laboratories Male Medical sciences Medicine Medicine & Public Health Mice Middle Aged mRNA Mutation Neuregulin Neuregulins - genetics Neuregulins - metabolism Neurosciences Nicotine Nicotine - pharmacology original-article Pharmacotherapy Polymorphism, Single Nucleotide - genetics Protein-tyrosine kinase receptors Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quinazolines - pharmacology Rats Receptor, ErbB-4 - antagonists & inhibitors Single-nucleotide polymorphism Smoking - drug therapy Smoking - genetics Smoking cessation Stainless steel Substance Withdrawal Syndrome - genetics Tobacco habit Tobacco smoking Tobacco Use Cessation Products Tobacco Use Disorder - genetics Tobacco, tobacco smoking Toxicology Treatments Whole genome sequencing Withdrawal Young Adult
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