Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan
This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the meth...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-11 |
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| creator | Liu, Ray-H. Wang, Shing-Yaw Tang, Tze-Chun Chang, Wei Chiao Tang, Hsin-Pei Sheu, Yuh-Ling Li, Jih-Heng Lee, Hsin-Ya Yeh, Yi-Chun |
| description | This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP. |
| doi_str_mv | 10.1155/2013/741403 |
| format | Article |
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A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/741403</identifier><identifier>PMID: 24455721</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Alleles ; Aryl Hydrocarbon Hydroxylases - genetics ; ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ; Care and treatment ; Cytochrome P-450 ; Cytochrome P-450 CYP2B6 ; Cytochrome P-450 CYP2C19 ; Demography ; Drug therapy ; Female ; Genetic aspects ; Genetic polymorphisms ; Health aspects ; Hepatitis C virus ; Heroin Dependence - drug therapy ; Heroin Dependence - genetics ; HIV ; HIV Infections - drug therapy ; Human immunodeficiency virus ; Humans ; Male ; Methadone ; Methadone - blood ; Methadone - therapeutic use ; Methadone hydrochloride ; Middle Aged ; Opiate Substitution Treatment - methods ; Physiological aspects ; Pilot Projects ; Precision Medicine ; Substance abuse ; Substance abuse treatment ; Taiwan ; Treatment Outcome</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-11</ispartof><rights>Copyright © 2013 Hsin-Ya Lee et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Hsin-Ya Lee et al. Hsin-Ya Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Hsin-Ya Lee et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-4fdd950cd9d79bdb80bb7ac8c627e1449877c49e55e5d3e77f57f8e60f8323f53</citedby><cites>FETCH-LOGICAL-c528t-4fdd950cd9d79bdb80bb7ac8c627e1449877c49e55e5d3e77f57f8e60f8323f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876825/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876825/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24455721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shi, Dongquan</contributor><creatorcontrib>Liu, Ray-H.</creatorcontrib><creatorcontrib>Wang, Shing-Yaw</creatorcontrib><creatorcontrib>Tang, Tze-Chun</creatorcontrib><creatorcontrib>Chang, Wei Chiao</creatorcontrib><creatorcontrib>Tang, Hsin-Pei</creatorcontrib><creatorcontrib>Sheu, Yuh-Ling</creatorcontrib><creatorcontrib>Li, Jih-Heng</creatorcontrib><creatorcontrib>Lee, Hsin-Ya</creatorcontrib><creatorcontrib>Yeh, Yi-Chun</creatorcontrib><title>Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.</description><subject>Adult</subject><subject>Alleles</subject><subject>Aryl Hydrocarbon Hydroxylases - genetics</subject><subject>ATP Binding Cassette Transporter, Sub-Family B</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - genetics</subject><subject>Care and treatment</subject><subject>Cytochrome P-450</subject><subject>Cytochrome P-450 CYP2B6</subject><subject>Cytochrome P-450 CYP2C19</subject><subject>Demography</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Health aspects</subject><subject>Hepatitis C virus</subject><subject>Heroin Dependence - drug therapy</subject><subject>Heroin Dependence - genetics</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Methadone</subject><subject>Methadone - blood</subject><subject>Methadone - therapeutic use</subject><subject>Methadone hydrochloride</subject><subject>Middle Aged</subject><subject>Opiate Substitution Treatment - methods</subject><subject>Physiological aspects</subject><subject>Pilot Projects</subject><subject>Precision Medicine</subject><subject>Substance abuse</subject><subject>Substance abuse treatment</subject><subject>Taiwan</subject><subject>Treatment Outcome</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1vEzEQhlcIRKvSE3dkiQsChfpzvcsBKarKh9SICMLZcuzZxNXGTm1vqvI7-MF4lRICJ3yxZ_zMO2PrrarnBL8lRIgLigm7kJxwzB5Vp5QRPqkJJ48PZ8ZOqvOUbnBZDalxWz-tTijnQkhKTqufs7BzfoVyuNPRojnEFLzu3Q-waAbWGecBOY_yGkqc19qGkphp5zN47Q2gRQSdN-AzmsewinrzDk3R3PUho295sPco7KuvdrofdHYlDN1R1VdI2-ATpLHNQrs77Z9VTzrdJzh_2M-q7x-uFpefJtdfPn6-nF5PjKBNnvDO2lZgY1sr26VdNni5lNo0pqYSCOdtI6XhLQgBwjKQshOya6DGXcMo6wQ7q97vdbfDcgPWlHGi7tU2uo2O9ypop_6-8W6tVmGnWCPrho4Crx4EYrgdIGW1cclA32sPYUiK8JbWWHDaFvTlP-hNGGL56pGSdc0owewPtdI9KOe7UPqaUVRNOZWYcoZ5od7sKRNDShG6w8gEq9EWarSF2tui0C-OX3lgf5ugAK_3wNp5q-_c_6lBQaDTRzDDTc3ZL7g7ydQ</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Liu, Ray-H.</creator><creator>Wang, Shing-Yaw</creator><creator>Tang, Tze-Chun</creator><creator>Chang, Wei Chiao</creator><creator>Tang, Hsin-Pei</creator><creator>Sheu, Yuh-Ling</creator><creator>Li, Jih-Heng</creator><creator>Lee, Hsin-Ya</creator><creator>Yeh, Yi-Chun</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan</title><author>Liu, Ray-H. ; Wang, Shing-Yaw ; Tang, Tze-Chun ; Chang, Wei Chiao ; Tang, Hsin-Pei ; Sheu, Yuh-Ling ; Li, Jih-Heng ; Lee, Hsin-Ya ; Yeh, Yi-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-4fdd950cd9d79bdb80bb7ac8c627e1449877c49e55e5d3e77f57f8e60f8323f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Aryl Hydrocarbon Hydroxylases - genetics</topic><topic>ATP Binding Cassette Transporter, Sub-Family B</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - genetics</topic><topic>Care and treatment</topic><topic>Cytochrome P-450</topic><topic>Cytochrome P-450 CYP2B6</topic><topic>Cytochrome P-450 CYP2C19</topic><topic>Demography</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Health aspects</topic><topic>Hepatitis C virus</topic><topic>Heroin Dependence - drug therapy</topic><topic>Heroin Dependence - genetics</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Male</topic><topic>Methadone</topic><topic>Methadone - blood</topic><topic>Methadone - therapeutic use</topic><topic>Methadone hydrochloride</topic><topic>Middle Aged</topic><topic>Opiate Substitution Treatment - methods</topic><topic>Physiological aspects</topic><topic>Pilot Projects</topic><topic>Precision Medicine</topic><topic>Substance abuse</topic><topic>Substance abuse treatment</topic><topic>Taiwan</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ray-H.</creatorcontrib><creatorcontrib>Wang, Shing-Yaw</creatorcontrib><creatorcontrib>Tang, Tze-Chun</creatorcontrib><creatorcontrib>Chang, Wei Chiao</creatorcontrib><creatorcontrib>Tang, Hsin-Pei</creatorcontrib><creatorcontrib>Sheu, Yuh-Ling</creatorcontrib><creatorcontrib>Li, Jih-Heng</creatorcontrib><creatorcontrib>Lee, Hsin-Ya</creatorcontrib><creatorcontrib>Yeh, Yi-Chun</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24455721</pmid><doi>10.1155/2013/741403</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BioMed research international, 2013-01, Vol.2013 (2013), p.1-11 |
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| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Alleles Aryl Hydrocarbon Hydroxylases - genetics ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Care and treatment Cytochrome P-450 Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP2C19 Demography Drug therapy Female Genetic aspects Genetic polymorphisms Health aspects Hepatitis C virus Heroin Dependence - drug therapy Heroin Dependence - genetics HIV HIV Infections - drug therapy Human immunodeficiency virus Humans Male Methadone Methadone - blood Methadone - therapeutic use Methadone hydrochloride Middle Aged Opiate Substitution Treatment - methods Physiological aspects Pilot Projects Precision Medicine Substance abuse Substance abuse treatment Taiwan Treatment Outcome |
| title | Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan |
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