The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst

Despite metronidazole's widespread clinical use since the 1960s, the specific enzymes involved in its biotransformation have not been previously identified. Hence, in vitro studies were conducted to identify and characterize the cytochrome P450 enzymes involved in the formation of the major met...

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Veröffentlicht in:	Drug metabolism and disposition 2013-09, Vol.41 (9), p.1686-1694
Hauptverfasser:	Pearce, Robin E, Cohen-Wolkowiez, Michael, Sampson, Mario R, Kearns, Gregory L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Catalysis Cytochrome P-450 CYP3A - metabolism Female Humans Kinetics Male Metronidazole - analogs & derivatives Metronidazole - metabolism Microsomes, Liver - enzymology Microsomes, Liver - metabolism
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