Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex

Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1, and multidrug resistance-linked P-glycoprotein (P-gp) or ABCB1 was quantified in frozen human livers (n = 64) and cryopreserved human hepatocytes (n = 12) by a validated li...

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Veröffentlicht in:	Drug metabolism and disposition 2014-01, Vol.42 (1), p.78-88
Hauptverfasser:	Prasad, Bhagwat, Evers, Raymond, Gupta, Anshul, Hop, Cornelis E C A, Salphati, Laurent, Shukla, Suneet, Ambudkar, Suresh V, Unadkat, Jashvant D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Carbamates - metabolism Child Child, Preschool Chromatography, Liquid - methods Female Fluorobenzenes - metabolism Haplotypes - genetics Hepatocytes - metabolism Humans Individuality Infant Liver - metabolism Male Middle Aged Organic Anion Transporters - genetics Piperidines - metabolism Polymorphism, Single Nucleotide - genetics Pyrimidines - metabolism Rosuvastatin Calcium Sulfonamides - metabolism Tandem Mass Spectrometry - methods Young Adult
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