BAF chromatin remodeling complex: Cortical size regulation and beyond
The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2013-09, Vol.12 (18), p.2953-2959 |
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| creator | Cong Tuoc, Tran Narayanan, Ramanathan Stoykova, Anastassia |
| description | The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size. |
| doi_str_mv | 10.4161/cc.25999 |
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Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.25999</identifier><identifier>PMID: 23974113</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; BAF complex ; Body Size ; Chromatin - metabolism ; Chromatin Assembly and Disassembly - physiology ; chromatin regulation ; Chromosomal Proteins, Non-Histone - antagonists & inhibitors ; Chromosomal Proteins, Non-Histone - genetics ; Chromosomal Proteins, Non-Histone - metabolism ; cortical size ; Embryo, Mammalian - metabolism ; Embryonic Development ; Extra Views ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; intermediate progenitor ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Paired Box Transcription Factors - deficiency ; Paired Box Transcription Factors - genetics ; Paired Box Transcription Factors - metabolism ; Pax6 ; PAX6 Transcription Factor ; Repressor Proteins - deficiency ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; RNA Interference ; RNA, Small Interfering - metabolism ; Transcription Factors - metabolism</subject><ispartof>Cell cycle (Georgetown, Tex.), 2013-09, Vol.12 (18), p.2953-2959</ispartof><rights>Copyright © 2013 Landes Bioscience 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-d767db10a6dad8a3afca87c61366b5ed0a8f89095909f1e951e50df5bd1a90a23</citedby><cites>FETCH-LOGICAL-c482t-d767db10a6dad8a3afca87c61366b5ed0a8f89095909f1e951e50df5bd1a90a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875669/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875669/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23974113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cong Tuoc, Tran</creatorcontrib><creatorcontrib>Narayanan, Ramanathan</creatorcontrib><creatorcontrib>Stoykova, Anastassia</creatorcontrib><title>BAF chromatin remodeling complex: Cortical size regulation and beyond</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size.</description><subject>Animals</subject><subject>BAF complex</subject><subject>Body Size</subject><subject>Chromatin - metabolism</subject><subject>Chromatin Assembly and Disassembly - physiology</subject><subject>chromatin regulation</subject><subject>Chromosomal Proteins, Non-Histone - antagonists & inhibitors</subject><subject>Chromosomal Proteins, Non-Histone - genetics</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>cortical size</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryonic Development</subject><subject>Extra Views</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>intermediate progenitor</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Paired Box Transcription Factors - deficiency</subject><subject>Paired Box Transcription Factors - genetics</subject><subject>Paired Box Transcription Factors - metabolism</subject><subject>Pax6</subject><subject>PAX6 Transcription Factor</subject><subject>Repressor Proteins - deficiency</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>RNA Interference</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Transcription Factors - metabolism</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLJTEQRoM4jK8Bf4H00k1rqtPpTlwIevEFwmzGdahO0tdIOrkmfdXrr7cdXzO4KKqgDqeKj5BdoAc1NHCo9UHFpZRrZBM4h7KmlK-_zkyUNVDYIFs531FaiVbCT7JRMdnWAGyTnJ2enBf6NsUBRxeKZIdorHdhXug4LLx9OipmMY1Ooy-ye7YTMV_6iY2hwGCKzq5iMDvkR48-21_vfZvcnJ_9mV2W178vrmYn16WuRTWWpm1a0wHFxqARyLDXKFrdAGuajltDUfRCUsmn6sFKDpZT0_POAEqKFdsmx2_exbIbrNE2jAm9WiQ3YFqpiE79vwnuVs3jg2Ki5U0jJ8H-uyDF-6XNoxpc1tZ7DDYus4KatVwwVtVfqE4x52T7zzNA1WvqSmv1N_UJ3fv3rU_wI-YJYG-AC31MAz7G5I0aceVj6hMG7bJi37QvFzCP6Q</recordid><startdate>20130915</startdate><enddate>20130915</enddate><creator>Cong Tuoc, Tran</creator><creator>Narayanan, Ramanathan</creator><creator>Stoykova, Anastassia</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130915</creationdate><title>BAF chromatin remodeling complex: Cortical size regulation and beyond</title><author>Cong Tuoc, Tran ; Narayanan, Ramanathan ; Stoykova, Anastassia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-d767db10a6dad8a3afca87c61366b5ed0a8f89095909f1e951e50df5bd1a90a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>BAF complex</topic><topic>Body Size</topic><topic>Chromatin - metabolism</topic><topic>Chromatin Assembly and Disassembly - physiology</topic><topic>chromatin regulation</topic><topic>Chromosomal Proteins, Non-Histone - antagonists & inhibitors</topic><topic>Chromosomal Proteins, Non-Histone - genetics</topic><topic>Chromosomal Proteins, Non-Histone - metabolism</topic><topic>cortical size</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryonic Development</topic><topic>Extra Views</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>intermediate progenitor</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Paired Box Transcription Factors - deficiency</topic><topic>Paired Box Transcription Factors - genetics</topic><topic>Paired Box Transcription Factors - metabolism</topic><topic>Pax6</topic><topic>PAX6 Transcription Factor</topic><topic>Repressor Proteins - deficiency</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>RNA Interference</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cong Tuoc, Tran</creatorcontrib><creatorcontrib>Narayanan, Ramanathan</creatorcontrib><creatorcontrib>Stoykova, Anastassia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cong Tuoc, Tran</au><au>Narayanan, Ramanathan</au><au>Stoykova, Anastassia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BAF chromatin remodeling complex: Cortical size regulation and beyond</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2013-09-15</date><risdate>2013</risdate><volume>12</volume><issue>18</issue><spage>2953</spage><epage>2959</epage><pages>2953-2959</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>23974113</pmid><doi>10.4161/cc.25999</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals BAF complex Body Size Chromatin - metabolism Chromatin Assembly and Disassembly - physiology chromatin regulation Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism cortical size Embryo, Mammalian - metabolism Embryonic Development Extra Views Eye Proteins - genetics Eye Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism intermediate progenitor Mice Mice, Inbred C57BL Mice, Knockout Paired Box Transcription Factors - deficiency Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax6 PAX6 Transcription Factor Repressor Proteins - deficiency Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference RNA, Small Interfering - metabolism Transcription Factors - metabolism |
| title | BAF chromatin remodeling complex: Cortical size regulation and beyond |
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