High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

•High glucose enhances respiration (metabolism of glucose) in cerebral pericytes.•Enhanced respiration leads to overproduction of reactive oxygen species (ROS).•ROS damage pericytes in microvasculature of insulin insensitive tissues.•Inhibition of mitochondrial carbonic anhydrases (mCAs) slows respi...

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