Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status

•Nrf2 activation attenuates inflammatory gene expression in hyperoxia exposed neonatal lung.•Induction of cell cycle regulatory genes in chronic hyperoxia is Nrf2 independent in neonatal lung.•Nrf2 inducers may limit neonatal lung injury in hyperoxia by mediating lung inflammation. Hyperoxia exposur...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2014-01, Vol.65 (1), p.4-9
Hauptverfasser:	McGrath-Morrow, Sharon A., Lauer, Thomas, Collaco, Joseph M., Lopez, Armando, Malhotra, Deepti, Alekseyev, Yuriy O., Neptune, Enid, Wise, Robert, Biswal, Shyam
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobiosis - genetics Alveolar growth inhibition Animals Animals, Newborn - genetics Animals, Newborn - metabolism Anticarcinogenic Agents - pharmacology Cell Cycle - genetics Cell cycle regulatory genes Chronic lung disease of prematurity Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Female Gene Expression Profiling Hyperoxia Inflammation Interleukin-6 - biosynthesis Interleukin-6 - genetics Isothiocyanates - pharmacology Lung - metabolism Mice Mice, Transgenic NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress - genetics Oxygen - toxicity Pregnancy Prenatal Exposure Delayed Effects Transcription, Genetic
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