Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors
Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However,...
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| Veröffentlicht in: | Environment international 2014-01, Vol.62, p.1-11 |
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| creator | Cantonwine, David E. Cordero, José F. Rivera-González, Luis O. Anzalota Del Toro, Liza V. Ferguson, Kelly K. Mukherjee, Bhramar Calafat, Antonia M. Crespo, Noe Jiménez-Vélez, Braulio Padilla, Ingrid Y. Alshawabkeh, Akram N. Meeker, John D. |
| description | Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, information on exposure to phthalates from a variety of sources in Puerto Rico is lacking. The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico.
We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18±2weeks, 22±2weeks, and 26±2weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP).
Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolite concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP).
To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure.
•Phthalate exposure is prevalent among pregnant women in Puerto Rico.•Compared to the US, urinary phthalate concentrations in Puerto Rico were different.•Within-subject repeatability of phthalates were low to moderate.•Monoethyl p |
| doi_str_mv | 10.1016/j.envint.2013.09.014 |
| format | Article |
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We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18±2weeks, 22±2weeks, and 26±2weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP).
Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolite concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP).
To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure.
•Phthalate exposure is prevalent among pregnant women in Puerto Rico.•Compared to the US, urinary phthalate concentrations in Puerto Rico were different.•Within-subject repeatability of phthalates were low to moderate.•Monoethyl phthalate levels were higher among women who used perfume or cosmetics.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2013.09.014</identifier><identifier>PMID: 24161445</identifier><identifier>CODEN: ENVIDV</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; aquifers ; Biological and medical sciences ; Biomarkers ; Biomarkers - urine ; coasts ; correlation ; Endocrine disruptor ; Environment ; Environment. Living conditions ; Environmental pollutants toxicology ; Epidemiology ; Exposure ; Female ; Gestation ; Humans ; Karst ; karsts ; Medical sciences ; Metabolites ; personal care products ; Phthalates ; Phthalic Acids - urine ; Populations ; Pregnancy ; Pregnant Women ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Puerto Rico ; questionnaires ; Reproducibility of Results ; Surveys and Questionnaires ; Temporal logic ; temporal variation ; Time Factors ; Toxicology ; United States ; Urine ; Water Pollutants, Chemical - urine ; water utilization ; Young Adult</subject><ispartof>Environment international, 2014-01, Vol.62, p.1-11</ispartof><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013.</rights><rights>2013 Elsevier Ltd. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-7c8e24384bfc1c6886e6183ae870c768e3083dcf296a7a591240062a8258b40d3</citedby><cites>FETCH-LOGICAL-c592t-7c8e24384bfc1c6886e6183ae870c768e3083dcf296a7a591240062a8258b40d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0160412013002080$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28040568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24161445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cantonwine, David E.</creatorcontrib><creatorcontrib>Cordero, José F.</creatorcontrib><creatorcontrib>Rivera-González, Luis O.</creatorcontrib><creatorcontrib>Anzalota Del Toro, Liza V.</creatorcontrib><creatorcontrib>Ferguson, Kelly K.</creatorcontrib><creatorcontrib>Mukherjee, Bhramar</creatorcontrib><creatorcontrib>Calafat, Antonia M.</creatorcontrib><creatorcontrib>Crespo, Noe</creatorcontrib><creatorcontrib>Jiménez-Vélez, Braulio</creatorcontrib><creatorcontrib>Padilla, Ingrid Y.</creatorcontrib><creatorcontrib>Alshawabkeh, Akram N.</creatorcontrib><creatorcontrib>Meeker, John D.</creatorcontrib><title>Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors</title><title>Environment international</title><addtitle>Environ Int</addtitle><description>Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, information on exposure to phthalates from a variety of sources in Puerto Rico is lacking. The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico.
We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18±2weeks, 22±2weeks, and 26±2weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP).
Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolite concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP).
To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure.
•Phthalate exposure is prevalent among pregnant women in Puerto Rico.•Compared to the US, urinary phthalate concentrations in Puerto Rico were different.•Within-subject repeatability of phthalates were low to moderate.•Monoethyl phthalate levels were higher among women who used perfume or cosmetics.</description><subject>Adult</subject><subject>aquifers</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>coasts</subject><subject>correlation</subject><subject>Endocrine disruptor</subject><subject>Environment</subject><subject>Environment. Living conditions</subject><subject>Environmental pollutants toxicology</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Gestation</subject><subject>Humans</subject><subject>Karst</subject><subject>karsts</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>personal care products</subject><subject>Phthalates</subject><subject>Phthalic Acids - urine</subject><subject>Populations</subject><subject>Pregnancy</subject><subject>Pregnant Women</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Puerto Rico</subject><subject>questionnaires</subject><subject>Reproducibility of Results</subject><subject>Surveys and Questionnaires</subject><subject>Temporal logic</subject><subject>temporal variation</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>United States</subject><subject>Urine</subject><subject>Water Pollutants, Chemical - urine</subject><subject>water utilization</subject><subject>Young Adult</subject><issn>0160-4120</issn><issn>1873-6750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt1uEzEQhVcIRNPCGyDkGyQuusF_6_VygYTKr1QBQvTamvVOEke7drCdoL5DHxpHCS3cADe2pfnmaOb4VNUTRueMMvViPUe_cz7POWViTrs5ZfJeNWO6FbVqG3q_mhWM1pJxelKdprSmlHKpm4fVCZdMMSmbWXVzFZ2HeE02q7yCETKSCTP0YXTlaYO36HOE7IJPBKbgl2QTcenBZ_IjTOiJ8-RTiHmF0ZMvW4w5kK_OhpfkjUs5un677z0nGadNiDCSHUQHvSv61-cE_LDXG5zNIaZH1YMFjAkfH--z6urd228XH-rLz-8_Xry-rG3T8Vy3ViOXQst-YZlVWitUTAtA3VLbKo2CajHYBe8UtNB0jEtKFQfNG91LOoiz6tVBd7PtJxwOK45mE91UrDABnPmz4t3KLMPOCN0WA7si8PwoEMP3LaZsJpcsjiN4DNtkeLFa8LbhzT9RpnTTduX4H7RVQinKRUHlAbUxpBRxcTs8o2YfD7M2h3iYfTwM7UyJR2l7-vvit02_8lCAZ0cAkoVxEcFbl-44TSVtlL5zEMs37RxGk6zDEpbBRbTZDMH9fZKfyeXdsQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Cantonwine, David E.</creator><creator>Cordero, José F.</creator><creator>Rivera-González, Luis O.</creator><creator>Anzalota Del Toro, Liza V.</creator><creator>Ferguson, Kelly K.</creator><creator>Mukherjee, Bhramar</creator><creator>Calafat, Antonia M.</creator><creator>Crespo, Noe</creator><creator>Jiménez-Vélez, Braulio</creator><creator>Padilla, Ingrid Y.</creator><creator>Alshawabkeh, Akram N.</creator><creator>Meeker, John D.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TV</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H96</scope><scope>L.G</scope><scope>SOI</scope><scope>7SU</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors</title><author>Cantonwine, David E. ; Cordero, José F. ; Rivera-González, Luis O. ; Anzalota Del Toro, Liza V. ; Ferguson, Kelly K. ; Mukherjee, Bhramar ; Calafat, Antonia M. ; Crespo, Noe ; Jiménez-Vélez, Braulio ; Padilla, Ingrid Y. ; Alshawabkeh, Akram N. ; Meeker, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-7c8e24384bfc1c6886e6183ae870c768e3083dcf296a7a591240062a8258b40d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>aquifers</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>coasts</topic><topic>correlation</topic><topic>Endocrine disruptor</topic><topic>Environment</topic><topic>Environment. Living conditions</topic><topic>Environmental pollutants toxicology</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Gestation</topic><topic>Humans</topic><topic>Karst</topic><topic>karsts</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>personal care products</topic><topic>Phthalates</topic><topic>Phthalic Acids - urine</topic><topic>Populations</topic><topic>Pregnancy</topic><topic>Pregnant Women</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Puerto Rico</topic><topic>questionnaires</topic><topic>Reproducibility of Results</topic><topic>Surveys and Questionnaires</topic><topic>Temporal logic</topic><topic>temporal variation</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>United States</topic><topic>Urine</topic><topic>Water Pollutants, Chemical - urine</topic><topic>water utilization</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cantonwine, David E.</creatorcontrib><creatorcontrib>Cordero, José F.</creatorcontrib><creatorcontrib>Rivera-González, Luis O.</creatorcontrib><creatorcontrib>Anzalota Del Toro, Liza V.</creatorcontrib><creatorcontrib>Ferguson, Kelly K.</creatorcontrib><creatorcontrib>Mukherjee, Bhramar</creatorcontrib><creatorcontrib>Calafat, Antonia M.</creatorcontrib><creatorcontrib>Crespo, Noe</creatorcontrib><creatorcontrib>Jiménez-Vélez, Braulio</creatorcontrib><creatorcontrib>Padilla, Ingrid Y.</creatorcontrib><creatorcontrib>Alshawabkeh, Akram N.</creatorcontrib><creatorcontrib>Meeker, John D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environment international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cantonwine, David E.</au><au>Cordero, José F.</au><au>Rivera-González, Luis O.</au><au>Anzalota Del Toro, Liza V.</au><au>Ferguson, Kelly K.</au><au>Mukherjee, Bhramar</au><au>Calafat, Antonia M.</au><au>Crespo, Noe</au><au>Jiménez-Vélez, Braulio</au><au>Padilla, Ingrid Y.</au><au>Alshawabkeh, Akram N.</au><au>Meeker, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors</atitle><jtitle>Environment international</jtitle><addtitle>Environ Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>62</volume><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0160-4120</issn><eissn>1873-6750</eissn><coden>ENVIDV</coden><abstract>Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, information on exposure to phthalates from a variety of sources in Puerto Rico is lacking. The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico.
We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18±2weeks, 22±2weeks, and 26±2weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP).
Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolite concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP).
To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure.
•Phthalate exposure is prevalent among pregnant women in Puerto Rico.•Compared to the US, urinary phthalate concentrations in Puerto Rico were different.•Within-subject repeatability of phthalates were low to moderate.•Monoethyl phthalate levels were higher among women who used perfume or cosmetics.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>24161445</pmid><doi>10.1016/j.envint.2013.09.014</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environment international, 2014-01, Vol.62, p.1-11 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult aquifers Biological and medical sciences Biomarkers Biomarkers - urine coasts correlation Endocrine disruptor Environment Environment. Living conditions Environmental pollutants toxicology Epidemiology Exposure Female Gestation Humans Karst karsts Medical sciences Metabolites personal care products Phthalates Phthalic Acids - urine Populations Pregnancy Pregnant Women Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Puerto Rico questionnaires Reproducibility of Results Surveys and Questionnaires Temporal logic temporal variation Time Factors Toxicology United States Urine Water Pollutants, Chemical - urine water utilization Young Adult |
| title | Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors |
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