Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

Key Points Mining increasingly comprehensive chromatin interaction maps for chromosomal domains and complete genomes requires novel computational methods and modelling tools. Looping interactions between specific genomic elements — for example, gene promoters and regulatory elements — can be identif...

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Veröffentlicht in:	Nature reviews. Genetics 2013-06, Vol.14 (6), p.390-403
Hauptverfasser:	Dekker, Job, Marti-Renom, Marc A., Mirny, Leonid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biomedicine Cancer Research Cell cycle Cell interaction Chromatin Chromatin - genetics Chromosome Mapping Chromosomes Chromosomes, Human - genetics DNA sequencing Epistasis, Genetic Gene Function Genetic regulation Genome, Human Human Genetics Humans Models, Genetic Nucleic Acid Conformation Nucleotide sequencing Properties review-article
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