Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion

Recurrent deletions at the 22q11.2 locus have been established as a strong genetic risk factor for the development of schizophrenia and cognitive dysfunction. Individuals with 22q11.2 deletions have a range of well-defined volumetric abnormalities in a number of critical brain structures. A mouse mo...

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Veröffentlicht in:	Molecular psychiatry 2014-01, Vol.19 (1), p.99-107
Hauptverfasser:	Ellegood, J, Markx, S, Lerch, J P, Steadman, P E, Genç, C, Provenzano, F, Kushner, S A, Henkelman, R M, Karayiorgou, M, Gogos, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 692/699/476/1799 692/700/1421/65 Alzheimer's disease Anatomy Animals Autism Behavioral Sciences Biological Psychology Biophysics Brain Brain - pathology Chromosome Deletion Cognitive ability Comparative analysis Diagnosis DiGeorge Syndrome - genetics DiGeorge Syndrome - pathology Disease Disease Models, Animal Gene mutations Genetic aspects Health aspects Health risk assessment Human subjects Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Neurosciences original-article Pharmacotherapy Phenotype Physiological aspects Physiology Psychiatry Risk factors Schizophrenia Third Ventricle - pathology Validity
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