Phase I drug-interaction study of effects of calcium and magnesium infusions on oxaliplatin pharmacokinetics and acute neurotoxicity in colorectal cancer patients

Calcium and magnesium (Ca/Mg) infusions have been suggested as an effective intervention for preventing oxaliplatin-induced neurotoxicity, but the effects of Ca/Mg infusions on oxaliplatin pharmacokinetics, motor nerve hyperexcitability and acute neurotoxicity symptoms are unclear. In this double bl...

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Veröffentlicht in:	BMC cancer 2013-10, Vol.13 (1), p.495-495, Article 495
Hauptverfasser:	Han, Catherine H, Khwaounjoo, Prashannata, Kilfoyle, Dean H, Hill, Andrew, McKeage, Mark J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antimitotic agents Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Calcium Calcium - administration & dosage Cancer patients Cancer therapies Chemotherapy Colorectal cancer Colorectal Neoplasms - complications Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cross-Over Studies Drug dosages Drug Interactions Drug therapy Female Health aspects Humans Magnesium Magnesium - administration & dosage Male Medical research Medicine, Experimental Middle Aged Neoplasm Staging Neurotoxicity Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - toxicity Oxaliplatin Patients Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - diagnosis Peripheral Nervous System Diseases - physiopathology Plasma Sample size Statistical analysis Studies Treatment Outcome
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