Polymorphism of HLA-DR β Chains in DR4, -7, and -9 Haplotypes: Implications for the Mechanisms of Allelic Variation

We have isolated and sequenced cDNA clones corresponding to the DRβ 1 and DRβ 2 loci from two homozygous B-cell lines typed as DR7 (Burkhart) and DR9 (ISK). These nucleotide sequences were compared to β 1 and β 2 chains of other DR haplotypes. The first-domain sequences of β 2 chains are identical i...

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