Chk1 Targeting Reactivates PP2A Tumor Suppressor Activity in Cancer Cells

Checkpoint kinase Chk1 is constitutively active in many cancer cell types and new generation Chk1 inhibitors show marked antitumor activity as single agents. Here we present a hitherto unrecognized mechanism that contributes to the response of cancer cells to Chk1-targeted therapy. Inhibiting chroni...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-11, Vol.73 (22), p.6757-6769
Hauptverfasser:	KHANNA, Anchit, KAUKO, Otto, POKHAREL, Yuba R, PIMANDA, John, RUSSEL, Mike R, HAGLUND, Caj, COLE, Kristina A, KLEFSTRÖM, Juha, AITTOKALLIO, Tero, WEISS, Carsten, RISTIMÄKI, Ari, VISAKORPI, Tapio, BÖCKELMAN, Camilla, WESTERMARCK, Jukka, LAINE, Anni, SCHRECK, Ilona, PARTANEN, Johanna I, SZWAJDA, Agnieszka, BORMANN, Stefanie, BILGEN, Turker, HELENIUS, Merja
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Autoantigens - genetics Autoantigens - metabolism Biological and medical sciences Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Checkpoint Kinase 1 Enzyme Activation - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Targeted Therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Protein Phosphatase 2 - metabolism Tumor Cells, Cultured Tumor Suppressor Proteins - metabolism Tumors
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