Plasma glial fibrillary acidic protein levels in children with sickle cell disease
To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infar...
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| Veröffentlicht in: | American journal of hematology 2011-05, Vol.86 (5), p.427-429 |
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| creator | Savage, William J. Barron‐Casella, Emily Fu, Zongming Dulloor, Pratima Williams, Lisa Crain, Barbara J. White, Desiree A. Jennings, Jacky M. Van Eyk, Jennifer E. Debaun, Michael R. Everett, Allen Casella, James F. |
| description | To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0.003); also, 16.0% (16/100) of children with SCD and cerebral infarct had GFAP elevations above the 95th percentile of healthy pediatric controls (P 5 0.04). Although not statistically significant, children with SCD and cerebral infarct had more elevated GFAP levels than with SCD and no infarct (16/100, 16.0% vs. 14/168, 8.3%; P 5 0.07). Children with SCD and acute brain ischemia had a higher proportion of elevated GFAP than SCD children with normal MRI (3/6, 50% vs.8.3%; P 5 0.01). GFAP was associated with elevated systolic blood pressure in the preceding year and correlated positively with white blood cell count and negatively with age and performance IQ. Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury. |
| doi_str_mv | 10.1002/ajh.21995 |
| format | Article |
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Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0.003); also, 16.0% (16/100) of children with SCD and cerebral infarct had GFAP elevations above the 95th percentile of healthy pediatric controls (P 5 0.04). Although not statistically significant, children with SCD and cerebral infarct had more elevated GFAP levels than with SCD and no infarct (16/100, 16.0% vs. 14/168, 8.3%; P 5 0.07). Children with SCD and acute brain ischemia had a higher proportion of elevated GFAP than SCD children with normal MRI (3/6, 50% vs.8.3%; P 5 0.01). GFAP was associated with elevated systolic blood pressure in the preceding year and correlated positively with white blood cell count and negatively with age and performance IQ. Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.21995</identifier><identifier>PMID: 21523806</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - physiopathology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Biomarkers - blood ; Brain Injuries - blood ; Brain Ischemia - diagnosis ; Brain Ischemia - etiology ; Cerebral Infarction - diagnosis ; Cerebral Infarction - etiology ; Cerebrovascular Disorders - diagnosis ; Cerebrovascular Disorders - etiology ; Child ; Child, Preschool ; Diseases of red blood cells ; Early Diagnosis ; Female ; Glial Fibrillary Acidic Protein - blood ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nerve Tissue Proteins - blood ; Severity of Illness Index ; Stroke - blood</subject><ispartof>American journal of hematology, 2011-05, Vol.86 (5), p.427-429</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4725-32b30f31b386d0131508e1d55c72710708abacd358e7d6ffd8de08ecdd82d43c3</citedby><cites>FETCH-LOGICAL-c4725-32b30f31b386d0131508e1d55c72710708abacd358e7d6ffd8de08ecdd82d43c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.21995$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.21995$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24108565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21523806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savage, William J.</creatorcontrib><creatorcontrib>Barron‐Casella, Emily</creatorcontrib><creatorcontrib>Fu, Zongming</creatorcontrib><creatorcontrib>Dulloor, Pratima</creatorcontrib><creatorcontrib>Williams, Lisa</creatorcontrib><creatorcontrib>Crain, Barbara J.</creatorcontrib><creatorcontrib>White, Desiree A.</creatorcontrib><creatorcontrib>Jennings, Jacky M.</creatorcontrib><creatorcontrib>Van Eyk, Jennifer E.</creatorcontrib><creatorcontrib>Debaun, Michael R.</creatorcontrib><creatorcontrib>Everett, Allen</creatorcontrib><creatorcontrib>Casella, James F.</creatorcontrib><title>Plasma glial fibrillary acidic protein levels in children with sickle cell disease</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0.003); also, 16.0% (16/100) of children with SCD and cerebral infarct had GFAP elevations above the 95th percentile of healthy pediatric controls (P 5 0.04). Although not statistically significant, children with SCD and cerebral infarct had more elevated GFAP levels than with SCD and no infarct (16/100, 16.0% vs. 14/168, 8.3%; P 5 0.07). Children with SCD and acute brain ischemia had a higher proportion of elevated GFAP than SCD children with normal MRI (3/6, 50% vs.8.3%; P 5 0.01). GFAP was associated with elevated systolic blood pressure in the preceding year and correlated positively with white blood cell count and negatively with age and performance IQ. Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brain Injuries - blood</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - etiology</subject><subject>Cerebral Infarction - diagnosis</subject><subject>Cerebral Infarction - etiology</subject><subject>Cerebrovascular Disorders - diagnosis</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of red blood cells</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Glial Fibrillary Acidic Protein - blood</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Severity of Illness Index</subject><subject>Stroke - blood</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9rVDEQxYModq0--AUkICI-bDuT3OTmvgilqFUKiuhzyE3mdrNm712T3ZZ-e7PuWv-ATzMwP87MmcPYU4QTBBCnbrk4Edh16h6bIXR6brQS99kMpMbaQ3fEHpWyBEBsDDxkRwKVkAb0jH3-lFxZOX6Vokt8iH2OKbl8y52PIXq-ztOG4sgTXVMqvHZ-EVPINPKbuFnwEv23RNxTSjzEQq7QY_ZgcKnQk0M9Zl_fvvlyfjG__Pju_fnZ5dw3rVBzKXoJg8ReGh0AJSowhEEp34oWoQXjeueDVIbaoIchmECV8CEYERrp5TF7vdddb_sVBU_jJrtk1zmuqgE7uWj_noxxYa-maytNW18hqsDLg0Cevm-pbOwqlp0TN9K0LdZoabr61aaSz_8hl9M2j9WdRYW6kdBqWalXe8rnqZRMw90tCHYXlK1B2Z9BVfbZn8ffkb-SqcCLA-CKd2nIbvSx_OYaBKP0Tuh0z93ERLf_32jPPlzsV_8Az2mqIw</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Savage, William J.</creator><creator>Barron‐Casella, Emily</creator><creator>Fu, Zongming</creator><creator>Dulloor, Pratima</creator><creator>Williams, Lisa</creator><creator>Crain, Barbara J.</creator><creator>White, Desiree A.</creator><creator>Jennings, Jacky M.</creator><creator>Van Eyk, Jennifer E.</creator><creator>Debaun, Michael R.</creator><creator>Everett, Allen</creator><creator>Casella, James F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201105</creationdate><title>Plasma glial fibrillary acidic protein levels in children with sickle cell disease</title><author>Savage, William J. ; Barron‐Casella, Emily ; Fu, Zongming ; Dulloor, Pratima ; Williams, Lisa ; Crain, Barbara J. ; White, Desiree A. ; Jennings, Jacky M. ; Van Eyk, Jennifer E. ; Debaun, Michael R. ; Everett, Allen ; Casella, James F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4725-32b30f31b386d0131508e1d55c72710708abacd358e7d6ffd8de08ecdd82d43c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Brain Injuries - blood</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - etiology</topic><topic>Cerebral Infarction - diagnosis</topic><topic>Cerebral Infarction - etiology</topic><topic>Cerebrovascular Disorders - diagnosis</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of red blood cells</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Glial Fibrillary Acidic Protein - blood</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Severity of Illness Index</topic><topic>Stroke - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savage, William J.</creatorcontrib><creatorcontrib>Barron‐Casella, Emily</creatorcontrib><creatorcontrib>Fu, Zongming</creatorcontrib><creatorcontrib>Dulloor, Pratima</creatorcontrib><creatorcontrib>Williams, Lisa</creatorcontrib><creatorcontrib>Crain, Barbara J.</creatorcontrib><creatorcontrib>White, Desiree A.</creatorcontrib><creatorcontrib>Jennings, Jacky M.</creatorcontrib><creatorcontrib>Van Eyk, Jennifer E.</creatorcontrib><creatorcontrib>Debaun, Michael R.</creatorcontrib><creatorcontrib>Everett, Allen</creatorcontrib><creatorcontrib>Casella, James F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savage, William J.</au><au>Barron‐Casella, Emily</au><au>Fu, Zongming</au><au>Dulloor, Pratima</au><au>Williams, Lisa</au><au>Crain, Barbara J.</au><au>White, Desiree A.</au><au>Jennings, Jacky M.</au><au>Van Eyk, Jennifer E.</au><au>Debaun, Michael R.</au><au>Everett, Allen</au><au>Casella, James F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma glial fibrillary acidic protein levels in children with sickle cell disease</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2011-05</date><risdate>2011</risdate><volume>86</volume><issue>5</issue><spage>427</spage><epage>429</epage><pages>427-429</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14 ± 0.37 vs. 0.07 ± 0.08 ng/mL; P 5 0.003); also, 16.0% (16/100) of children with SCD and cerebral infarct had GFAP elevations above the 95th percentile of healthy pediatric controls (P 5 0.04). Although not statistically significant, children with SCD and cerebral infarct had more elevated GFAP levels than with SCD and no infarct (16/100, 16.0% vs. 14/168, 8.3%; P 5 0.07). Children with SCD and acute brain ischemia had a higher proportion of elevated GFAP than SCD children with normal MRI (3/6, 50% vs.8.3%; P 5 0.01). GFAP was associated with elevated systolic blood pressure in the preceding year and correlated positively with white blood cell count and negatively with age and performance IQ. Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21523806</pmid><doi>10.1002/ajh.21995</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anemia, Sickle Cell - blood Anemia, Sickle Cell - physiopathology Anemias. Hemoglobinopathies Biological and medical sciences Biomarkers - blood Brain Injuries - blood Brain Ischemia - diagnosis Brain Ischemia - etiology Cerebral Infarction - diagnosis Cerebral Infarction - etiology Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - etiology Child Child, Preschool Diseases of red blood cells Early Diagnosis Female Glial Fibrillary Acidic Protein - blood Hematologic and hematopoietic diseases Hematology Humans Magnetic Resonance Imaging Male Medical sciences Nerve Tissue Proteins - blood Severity of Illness Index Stroke - blood |
| title | Plasma glial fibrillary acidic protein levels in children with sickle cell disease |
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