Anosmin-1 contributes to brain tumor malignancy through integrin signal pathways

Anosmin-1, encoded by the KAL1 gene, is an extracellular matrix (ECM)-associated protein which plays essential roles in the establishment of olfactory and GNRH neurons during early brain development. Loss-of-function mutations of KAL1 results in Kallmann syndrome with delayed puberty and anosmia. Th...

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Veröffentlicht in:	Endocrine-related cancer 2014-02, Vol.21 (1), p.85-99
Hauptverfasser:	Choy, Catherine T, Kim, Haseong, Lee, Ji-Young, Williams, David M, Palethorpe, David, Fellows, Greg, Wright, Alan J, Laing, Ken, Bridges, Leslie R, Howe, Franklyn A, Kim, Soo-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - physiology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Glioblastoma - metabolism Glioblastoma - pathology Heterografts Humans Integrin beta1 - metabolism Mice Mice, Inbred NOD Mice, SCID Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics Signal Transduction
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