Does oxidative inactivation of CD45 phosphatase in rheumatoid arthritis underlie immune hyporesponsiveness?

The protein tyrosine phosphatase (PTP) CD45 is critical in regulating the earliest steps in T-cell-receptor signaling but, similar to all PTPs, it is susceptible to oxidative inactivation. Given the widely reported effects of oxidant damage associated with rheumatoid arthritis (RA), we examined whet...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Antioxidants & redox signaling 2013-12, Vol.19 (18), p.2280-2285
Hauptverfasser:	Rider, David A, Bayley, Rachel, Clay, Elizabeth, Young, Stephen P
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Humans Leukocyte Common Antigens - antagonists & inhibitors Leukocyte Common Antigens - immunology Leukocyte Common Antigens - metabolism Oxidation-Reduction Oxidative Stress - immunology Views
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!