Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer

We have previously shown that SUM‐149 human breast cancer cells require an amphiregulin (AREG) autocrine loop for cell proliferation. We also demonstrated that AREG can increase epidermal growth factor receptor (EGFR) stability and promote EGFR localization to the plasma membrane. In the present stu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular physiology 2011-10, Vol.226 (10), p.2691-2701
Hauptverfasser:	Baillo, Andrea, Giroux, Craig, Ethier, Stephen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Cell Line, Tumor EGF Family of Proteins Female Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques - methods Glycoproteins - antagonists & inhibitors Glycoproteins - genetics Glycoproteins - physiology Humans Inflammatory Breast Neoplasms - genetics Inflammatory Breast Neoplasms - metabolism Inflammatory Breast Neoplasms - pathology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - physiology Neoplasm Invasiveness - pathology Phenotype Receptor, Epidermal Growth Factor - physiology RNA, Small Interfering - pharmacology Signal Transduction - genetics Signal Transduction - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!