GLIPR1 Tumor Suppressor Gene Expressed by Adenoviral Vector as Neoadjuvant Intraprostatic Injection for Localized Intermediate or High-Risk Prostate Cancer Preceding Radical Prostatectomy

GLIPR1 is upregulated by p53 in prostate cancer cells and has preclinical antitumor activity. A phase I clinical trial was conducted to evaluate the safety and activity of the neoadjuvant intraprostatic injection of GLIPR1 expressing adenovirus for intermediate or high-risk localized prostate cancer...

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Veröffentlicht in:	Clinical cancer research 2011-11, Vol.17 (22), p.7174-7182
Hauptverfasser:	SONPAVDE, Guru, THOMPSON, Timothy C, HAYES, Teresa G, ITTMANN, Michael M, WHEELER, Thomas M, GEE, Adrian, MILES, Brian J, KADMON, Dov, JAIN, Rajul K, AYALA, Gustavo E, KUROSAKA, Shinji, EDAMURA, Kohei, TABATA, Ken-Ichi, CHENGZHEN REN, GOLTSOV, Alexei A, MIMS, Martha P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Age Aged Antineoplastic agents Biological and medical sciences Gene Transfer Techniques Genes, Suppressor Genetic Therapy - methods Genetic Vectors Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Middle Aged Neoadjuvant Therapy Neoplasm Proteins - genetics Nephrology. Urinary tract diseases Nerve Tissue Proteins - genetics Pharmacology. Drug treatments Prostatectomy Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Prostatic Neoplasms - therapy Risk Tumors Tumors of the urinary system Urinary tract. Prostate gland
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