H2S‐induced pancreatic acinar cell apoptosis is mediated via JNK and p38 MAP kinase

Treatment of pancreatic acinar cells by hydrogen sulphide has been shown to induce apoptosis. However, a potential role of mitogen‐activated protein kinases (MAPKs) in this apoptotic pathway remains unknown. The present study examined the role of MAPKs in H2S‐induced apoptosis in mouse pancreatic ac...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2008-08, Vol.12 (4), p.1374-1383
Hauptverfasser:	Adhikari, Sharmila, Bhatia, Madhav
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Animals Annexin V Antibodies Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Biotechnology Carrier Proteins - metabolism Caspase 3 - metabolism Caspase-3 Cell activation Cell cycle Cell survival Cytochrome Cytochrome c Cytochromes c - metabolism Cytoplasm DIABLO protein Enzyme Activation - drug effects ERK Experiments Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fluorides H2S Hydrogen sulfide JNK JNK Mitogen-Activated Protein Kinases - metabolism Kinases Laboratory animals Male MAP kinase Metabolism Mice Mitochondria Mitochondrial Proteins - metabolism Models, Biological p38 p38 Mitogen-Activated Protein Kinases - metabolism Pancreas Pancreas, Exocrine - cytology Pancreas, Exocrine - enzymology Phosphoproteins - metabolism Phosphorylation Phosphorylation - drug effects Poly(ADP-ribose) Polymerases - metabolism Protein transport Protein Transport - drug effects Proteins Sulfides - pharmacology
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