Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects
Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis. Data were collected from the following electroni...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2013-12, Vol.17 (12), p.926-931 |
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| creator | Zou, Yan-Feng Tao, Jin-Hui Ye, Qian-Ling Pan, Hai-Feng Pan, Fa-Ming Su, Hong Ye, Dong-Qing |
| description | Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis.
Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.
A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between rs2228001 polymorphism and PCa (p>0.05). Similar results were found in stratification analyses by ethnicity and tumor stage. We detected a significant association of PAT+/-polymorphism with PCa (p0.05).
These analyses suggest that XPC gene PAT+/-polymorphism, but not rs2228001, likely contributes to susceptibility to PCa. |
| doi_str_mv | 10.1089/gtmb.2013.0267 |
| format | Article |
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Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.
A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between rs2228001 polymorphism and PCa (p>0.05). Similar results were found in stratification analyses by ethnicity and tumor stage. We detected a significant association of PAT+/-polymorphism with PCa (p<0.05). In stratification analysis, we did not detect a significant association of PAT+/-polymorphism with risk of bone metastasis in PCa patients (p>0.05).
These analyses suggest that XPC gene PAT+/-polymorphism, but not rs2228001, likely contributes to susceptibility to PCa.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2013.0267</identifier><identifier>PMID: 24093803</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Case-Control Studies ; DNA-Binding Proteins - genetics ; Genetic Predisposition to Disease ; Humans ; Male ; Neoplasm Proteins - genetics ; Original ; Polymorphism, Genetic ; Prostatic Neoplasms - genetics ; PubMed ; Risk Factors</subject><ispartof>Genetic testing and molecular biomarkers, 2013-12, Vol.17 (12), p.926-931</ispartof><rights>Copyright 2013, Mary Ann Liebert, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-137b28a6852b6f11a07df790864072ff98428ac5cb65e1327750e0e177fbe0da3</citedby><cites>FETCH-LOGICAL-c383t-137b28a6852b6f11a07df790864072ff98428ac5cb65e1327750e0e177fbe0da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24093803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Yan-Feng</creatorcontrib><creatorcontrib>Tao, Jin-Hui</creatorcontrib><creatorcontrib>Ye, Qian-Ling</creatorcontrib><creatorcontrib>Pan, Hai-Feng</creatorcontrib><creatorcontrib>Pan, Fa-Ming</creatorcontrib><creatorcontrib>Su, Hong</creatorcontrib><creatorcontrib>Ye, Dong-Qing</creatorcontrib><title>Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis.
Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.
A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between rs2228001 polymorphism and PCa (p>0.05). Similar results were found in stratification analyses by ethnicity and tumor stage. We detected a significant association of PAT+/-polymorphism with PCa (p<0.05). In stratification analysis, we did not detect a significant association of PAT+/-polymorphism with risk of bone metastasis in PCa patients (p>0.05).
These analyses suggest that XPC gene PAT+/-polymorphism, but not rs2228001, likely contributes to susceptibility to PCa.</description><subject>Case-Control Studies</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Neoplasm Proteins - genetics</subject><subject>Original</subject><subject>Polymorphism, Genetic</subject><subject>Prostatic Neoplasms - genetics</subject><subject>PubMed</subject><subject>Risk Factors</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctrGzEQxkVIadK01xyLjjnUjh6rx-YQCKYvCCSHFnoTWnlky-yutpKc4P--MklNcstpBuabj_nmh9A5JXNKdHu5KkM3Z4TyOWFSHaFT2jZiRphQx4deihP0IecNIbLhWr5HJ6whLdeEn6LNTc7RBVtCHHH0-M_9Aq9gBDzFfjfENK1DHjJ-DGWN8zY7mEroQh_KDpeIpxRzsQWws6ODdIXhISyhttinOGD-peWyrnUbcCV_RO-87TN8eq5n6Pe3r78WP2a3d99_Lm5uZ45rXmaUq45pK7VgnfSUWqKWXrVEy4Yo5n2rmzp2wnVSAOVMKUGAAFXKd0CWlp-h6yffadsNsHQwlmR7M6Uw2LQz0QbzejKGtVnFB1N_IySj1eDi2SDFv1vIxQyhJu97O0LcZkOl4lw3QrxB2kimZFPDVOn8Serq03ICf7iIErNnafYszZ6l2bOsC59f5jjI_8Pj_wAecpvv</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Zou, Yan-Feng</creator><creator>Tao, Jin-Hui</creator><creator>Ye, Qian-Ling</creator><creator>Pan, Hai-Feng</creator><creator>Pan, Fa-Ming</creator><creator>Su, Hong</creator><creator>Ye, Dong-Qing</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>201312</creationdate><title>Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects</title><author>Zou, Yan-Feng ; Tao, Jin-Hui ; Ye, Qian-Ling ; Pan, Hai-Feng ; Pan, Fa-Ming ; Su, Hong ; Ye, Dong-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-137b28a6852b6f11a07df790864072ff98428ac5cb65e1327750e0e177fbe0da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Case-Control Studies</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Neoplasm Proteins - genetics</topic><topic>Original</topic><topic>Polymorphism, Genetic</topic><topic>Prostatic Neoplasms - genetics</topic><topic>PubMed</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Yan-Feng</creatorcontrib><creatorcontrib>Tao, Jin-Hui</creatorcontrib><creatorcontrib>Ye, Qian-Ling</creatorcontrib><creatorcontrib>Pan, Hai-Feng</creatorcontrib><creatorcontrib>Pan, Fa-Ming</creatorcontrib><creatorcontrib>Su, Hong</creatorcontrib><creatorcontrib>Ye, Dong-Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Yan-Feng</au><au>Tao, Jin-Hui</au><au>Ye, Qian-Ling</au><au>Pan, Hai-Feng</au><au>Pan, Fa-Ming</au><au>Su, Hong</au><au>Ye, Dong-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2013-12</date><risdate>2013</risdate><volume>17</volume><issue>12</issue><spage>926</spage><epage>931</epage><pages>926-931</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis.
Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.
A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between rs2228001 polymorphism and PCa (p>0.05). Similar results were found in stratification analyses by ethnicity and tumor stage. We detected a significant association of PAT+/-polymorphism with PCa (p<0.05). In stratification analysis, we did not detect a significant association of PAT+/-polymorphism with risk of bone metastasis in PCa patients (p>0.05).
These analyses suggest that XPC gene PAT+/-polymorphism, but not rs2228001, likely contributes to susceptibility to PCa.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>24093803</pmid><doi>10.1089/gtmb.2013.0267</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Case-Control Studies DNA-Binding Proteins - genetics Genetic Predisposition to Disease Humans Male Neoplasm Proteins - genetics Original Polymorphism, Genetic Prostatic Neoplasms - genetics PubMed Risk Factors |
| title | Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects |
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