Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

Clostridium difficile infection is the main cause of healthcareacquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is import...

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Veröffentlicht in:	The Journal of infectious diseases 2014-01, Vol.209 (1), p.83-86
Hauptverfasser:	Kuehne, Sarah A., Collery, Mark M., Kelly, Michelle L., Cartman, Stephen T., Cockayne, Alan, Minton, Nigel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - genetics ADP Ribose Transferases - physiology Animals BACTERIA Bacterial Proteins - genetics Bacterial Proteins - physiology Bacterial Toxins - genetics Bacteriology Biological and medical sciences Cell Death Clostridioides difficile - genetics Clostridioides difficile - pathogenicity Clostridium difficile Clostridium Infections - microbiology Clostridium Infections - pathology Cricetinae Cytotoxicity Disease models Enterotoxins - genetics Enterotoxins - physiology Epidemiology Female Fundamental and applied biological sciences. Psychology HT29 Cells Humans Infections Infectious diseases Major and Brief Reports Medical sciences Mesocricetus Microbiology Miscellaneous Polymerase chain reaction Ribotyping Toxins Vero cells Virulence Virulence - genetics Virulence - physiology
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