Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia

Background. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated f...

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Veröffentlicht in:	The Journal of infectious diseases 2014-01, Vol.209 (1), p.120-129
Hauptverfasser:	Maude, Richard J., Silamut, Kamolrat, Plewes, Katherine, Charunwatthana, Prakaykaew, Ho, May, Faiz, M. Abul, Rahman, Ridwanur, Hossain, Md Amir, Hassan, Mahtab U., Yunus, Emran Bin, Hoque, Gofranul, Islam, Faridul, Ghose, Aniruddha, Hanson, Josh, Schlatter, Joel, Lacey, Rachel, Eastaugh, Alison, Taming, Joel, Lee, Sue J., White, Nicholas J., Chotivanich, Kesinee, Day, Nicholas P. J., Dondorp, Arjen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimalarials - pharmacokinetics Antimalarials - pharmacology Antimalarials - therapeutic use Biological and medical sciences Blood Blood plasma Clinical trials Erythrocytes Falciparum malaria Female Fundamental and applied biological sciences. Psychology Human protozoal diseases Humans Infectious diseases Kaplan-Meier Estimate Lactates Lactic Acid - blood Levamisole - pharmacokinetics Levamisole - pharmacology Levamisole - therapeutic use Major and Brief Reports Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - metabolism Malaria, Falciparum - parasitology Male Medical sciences Microbiology Microvessels - drug effects Middle Aged Parasitemia - drug therapy Parasitemia - parasitology Parasites Parasitic diseases Parasitism Plasmodium falciparum - chemistry Plasmodium falciparum - isolation & purification Protozoal diseases Regional Blood Flow Trophozoites
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