Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signature of immunosuppression manifested by upregulation of PD-1, P...

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Veröffentlicht in:	Cancer discovery 2013-12, Vol.3 (12), p.1355-1363
Hauptverfasser:	Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - metabolism Cell Line Cytokines - metabolism Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - immunology Lung Neoplasms - metabolism Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Transgenic Oncogenes Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Signal Transduction T-Lymphocytes - immunology Tumor Escape Tumor Microenvironment
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