Inhibitive Effects of Mulberry Leaf-Related Extracts on Cell Adhesion and Inflammatory Response in Human Aortic Endothelial Cells
Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kae...
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| creator | Chiu, C.-C. Chao, P.-Y. Yang, C.-M. Huang, M.-Y. Yang, Y.-Y. Lin, K.-H. |
| description | Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kaempferol. Polyphenols, flavonoids, and anthocyanidin also abounded in BT. The best trolox equivalent antioxidant capacity (TEAC) was generated from the acidic methanolic extracts of BT. Acidic methanolic and water extracts of mulberry leaf tea (MT), mulberry leaf (M), and BT significantly inhibited DNA oxidative damage to lymphocytes based on the comet assay as compared to the H2O2-treated group. TNF-α-induced monocyte-endothelial cell adhesion was significantly suppressed by MLREs. Additionally, nuclear factor kappa B (NF-κB) expression was significantly reduced by BT and MT. Significant reductions were also observed in both NF-κB and activator protein (AP)-1 DNA binding by MLREs. Significant increases in peroxisome proliferator-activated receptor (PPAR) α and γ DNA binding by MLREs were also detected in M and MT extracts, but no evidence for PPAR α DNA binding in 50 μg/mL MT extract was found. Apparently, MLREs can provide distinct cytoprotective mechanisms that may contribute to its putative beneficial effects on suppressing endothelial responses to cytokines during inflammation. |
| doi_str_mv | 10.1155/2013/267217 |
| format | Article |
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The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kaempferol. Polyphenols, flavonoids, and anthocyanidin also abounded in BT. The best trolox equivalent antioxidant capacity (TEAC) was generated from the acidic methanolic extracts of BT. Acidic methanolic and water extracts of mulberry leaf tea (MT), mulberry leaf (M), and BT significantly inhibited DNA oxidative damage to lymphocytes based on the comet assay as compared to the H2O2-treated group. TNF-α-induced monocyte-endothelial cell adhesion was significantly suppressed by MLREs. Additionally, nuclear factor kappa B (NF-κB) expression was significantly reduced by BT and MT. Significant reductions were also observed in both NF-κB and activator protein (AP)-1 DNA binding by MLREs. Significant increases in peroxisome proliferator-activated receptor (PPAR) α and γ DNA binding by MLREs were also detected in M and MT extracts, but no evidence for PPAR α DNA binding in 50 μg/mL MT extract was found. Apparently, MLREs can provide distinct cytoprotective mechanisms that may contribute to its putative beneficial effects on suppressing endothelial responses to cytokines during inflammation.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/267217</identifier><identifier>PMID: 24371453</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adhesion ; Antioxidants ; Aorta ; Apoptosis ; Atherosclerosis ; Cell adhesion ; Cell adhesion & migration ; Comet assay ; Deoxyribonucleic acid ; Diabetes ; DNA ; DNA damage ; Endothelial cells ; Flavonoids ; Flavonols ; Human behavior ; Hydrogen peroxide ; Inflammation ; Inflammatory response ; Kaempferol ; Leaves ; Lymphocytes ; Metabolites ; Monocytes ; NF-κB protein ; Nutrition ; Peroxisome proliferator-activated receptors ; Polyphenols ; Quercetin ; Tea ; Toxicity ; Transcription factors ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vitamin E</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-14</ispartof><rights>Copyright © 2013 P.-Y. Chao et al.</rights><rights>Copyright © 2013 P.-Y. Chao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 P.-Y. Chao et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d41be502df1854b741dc6bbed2c4bd4adc92eb45e359bf46d58abc086937504a3</citedby><cites>FETCH-LOGICAL-c466t-d41be502df1854b741dc6bbed2c4bd4adc92eb45e359bf46d58abc086937504a3</cites><orcidid>0000-0001-9024-3185 ; 0000-0001-9919-6645 ; 0000-0001-8754-3945</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863563/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863563/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24371453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sheu, Joen-Rong</contributor><creatorcontrib>Chiu, C.-C.</creatorcontrib><creatorcontrib>Chao, P.-Y.</creatorcontrib><creatorcontrib>Yang, C.-M.</creatorcontrib><creatorcontrib>Huang, M.-Y.</creatorcontrib><creatorcontrib>Yang, Y.-Y.</creatorcontrib><creatorcontrib>Lin, K.-H.</creatorcontrib><title>Inhibitive Effects of Mulberry Leaf-Related Extracts on Cell Adhesion and Inflammatory Response in Human Aortic Endothelial Cells</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kaempferol. Polyphenols, flavonoids, and anthocyanidin also abounded in BT. The best trolox equivalent antioxidant capacity (TEAC) was generated from the acidic methanolic extracts of BT. Acidic methanolic and water extracts of mulberry leaf tea (MT), mulberry leaf (M), and BT significantly inhibited DNA oxidative damage to lymphocytes based on the comet assay as compared to the H2O2-treated group. TNF-α-induced monocyte-endothelial cell adhesion was significantly suppressed by MLREs. Additionally, nuclear factor kappa B (NF-κB) expression was significantly reduced by BT and MT. Significant reductions were also observed in both NF-κB and activator protein (AP)-1 DNA binding by MLREs. Significant increases in peroxisome proliferator-activated receptor (PPAR) α and γ DNA binding by MLREs were also detected in M and MT extracts, but no evidence for PPAR α DNA binding in 50 μg/mL MT extract was found. Apparently, MLREs can provide distinct cytoprotective mechanisms that may contribute to its putative beneficial effects on suppressing endothelial responses to cytokines during inflammation.</description><subject>Adhesion</subject><subject>Antioxidants</subject><subject>Aorta</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Comet assay</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Endothelial cells</subject><subject>Flavonoids</subject><subject>Flavonols</subject><subject>Human behavior</subject><subject>Hydrogen peroxide</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Kaempferol</subject><subject>Leaves</subject><subject>Lymphocytes</subject><subject>Metabolites</subject><subject>Monocytes</subject><subject>NF-κB protein</subject><subject>Nutrition</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Polyphenols</subject><subject>Quercetin</subject><subject>Tea</subject><subject>Toxicity</subject><subject>Transcription factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Vitamin 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Effects of Mulberry Leaf-Related Extracts on Cell Adhesion and Inflammatory Response in Human Aortic Endothelial Cells</title><author>Chiu, C.-C. ; Chao, P.-Y. ; Yang, C.-M. ; Huang, M.-Y. ; Yang, Y.-Y. ; Lin, K.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d41be502df1854b741dc6bbed2c4bd4adc92eb45e359bf46d58abc086937504a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adhesion</topic><topic>Antioxidants</topic><topic>Aorta</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Comet assay</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Endothelial cells</topic><topic>Flavonoids</topic><topic>Flavonols</topic><topic>Human behavior</topic><topic>Hydrogen peroxide</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Kaempferol</topic><topic>Leaves</topic><topic>Lymphocytes</topic><topic>Metabolites</topic><topic>Monocytes</topic><topic>NF-κB protein</topic><topic>Nutrition</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Polyphenols</topic><topic>Quercetin</topic><topic>Tea</topic><topic>Toxicity</topic><topic>Transcription factors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiu, C.-C.</creatorcontrib><creatorcontrib>Chao, P.-Y.</creatorcontrib><creatorcontrib>Yang, C.-M.</creatorcontrib><creatorcontrib>Huang, M.-Y.</creatorcontrib><creatorcontrib>Yang, Y.-Y.</creatorcontrib><creatorcontrib>Lin, K.-H.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - 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Cells</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kaempferol. Polyphenols, flavonoids, and anthocyanidin also abounded in BT. The best trolox equivalent antioxidant capacity (TEAC) was generated from the acidic methanolic extracts of BT. Acidic methanolic and water extracts of mulberry leaf tea (MT), mulberry leaf (M), and BT significantly inhibited DNA oxidative damage to lymphocytes based on the comet assay as compared to the H2O2-treated group. TNF-α-induced monocyte-endothelial cell adhesion was significantly suppressed by MLREs. Additionally, nuclear factor kappa B (NF-κB) expression was significantly reduced by BT and MT. Significant reductions were also observed in both NF-κB and activator protein (AP)-1 DNA binding by MLREs. Significant increases in peroxisome proliferator-activated receptor (PPAR) α and γ DNA binding by MLREs were also detected in M and MT extracts, but no evidence for PPAR α DNA binding in 50 μg/mL MT extract was found. Apparently, MLREs can provide distinct cytoprotective mechanisms that may contribute to its putative beneficial effects on suppressing endothelial responses to cytokines during inflammation.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24371453</pmid><doi>10.1155/2013/267217</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9024-3185</orcidid><orcidid>https://orcid.org/0000-0001-9919-6645</orcidid><orcidid>https://orcid.org/0000-0001-8754-3945</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Adhesion Antioxidants Aorta Apoptosis Atherosclerosis Cell adhesion Cell adhesion & migration Comet assay Deoxyribonucleic acid Diabetes DNA DNA damage Endothelial cells Flavonoids Flavonols Human behavior Hydrogen peroxide Inflammation Inflammatory response Kaempferol Leaves Lymphocytes Metabolites Monocytes NF-κB protein Nutrition Peroxisome proliferator-activated receptors Polyphenols Quercetin Tea Toxicity Transcription factors Tumor necrosis factor-TNF Tumor necrosis factor-α Vitamin E |
| title | Inhibitive Effects of Mulberry Leaf-Related Extracts on Cell Adhesion and Inflammatory Response in Human Aortic Endothelial Cells |
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