On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms

Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and norm...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6158), p.590-590
Hauptverfasser:	Sun, Lu O., Jiang, Zheng, Rivlin-Etzion, Michal, Hand, Randal, Brady, Colleen M., Matsuoka, Ryota L., Yau, King-Wai, Feller, Maria B., Kolodkin, Alex L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amacrine cells Amacrine Cells - cytology Amacrine Cells - metabolism Amacrine Cells - physiology Animals Assembly Biological and medical sciences Cellular Circuits Dendrites - metabolism Dendrites - physiology Exhibits Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Ganglia Light Mice Mice, Mutant Strains Molecular biology Motion Motion Perception Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RESEARCH ARTICLE SUMMARY Retina Retina - metabolism Retina - physiology Semaphorins - genetics Semaphorins - metabolism Signal Transduction Sun Vertebrates: nervous system and sense organs Visual Stimuli Wiring
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