On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms
Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and norm...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6158), p.590-590 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Sun, Lu O. Jiang, Zheng Rivlin-Etzion, Michal Hand, Randal Brady, Colleen M. Matsuoka, Ryota L. Yau, King-Wai Feller, Maria B. Kolodkin, Alex L. |
| description | Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs. |
| doi_str_mv | 10.1126/science.1241974 |
| format | Article |
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Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1241974</identifier><identifier>PMID: 24179230</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Amacrine cells ; Amacrine Cells - cytology ; Amacrine Cells - metabolism ; Amacrine Cells - physiology ; Animals ; Assembly ; Biological and medical sciences ; Cellular ; Circuits ; Dendrites - metabolism ; Dendrites - physiology ; Exhibits ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Ganglia ; Light ; Mice ; Mice, Mutant Strains ; Molecular biology ; Motion ; Motion Perception ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neurons ; Receptors ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; RESEARCH ARTICLE SUMMARY ; Retina ; Retina - metabolism ; Retina - physiology ; Semaphorins - genetics ; Semaphorins - metabolism ; Signal Transduction ; Sun ; Vertebrates: nervous system and sense organs ; Visual Stimuli ; Wiring</subject><ispartof>Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.590-590</ispartof><rights>Copyright © 2013 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-2e6d331eee5b086ec282a3c3d2890e2e08ecf2d91d9f83aa6170213996128d4f3</citedby><cites>FETCH-LOGICAL-c605t-2e6d331eee5b086ec282a3c3d2890e2e08ecf2d91d9f83aa6170213996128d4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42619998$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42619998$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27975267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24179230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Lu O.</creatorcontrib><creatorcontrib>Jiang, Zheng</creatorcontrib><creatorcontrib>Rivlin-Etzion, Michal</creatorcontrib><creatorcontrib>Hand, Randal</creatorcontrib><creatorcontrib>Brady, Colleen M.</creatorcontrib><creatorcontrib>Matsuoka, Ryota L.</creatorcontrib><creatorcontrib>Yau, King-Wai</creatorcontrib><creatorcontrib>Feller, Maria B.</creatorcontrib><creatorcontrib>Kolodkin, Alex L.</creatorcontrib><title>On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.</description><subject>Amacrine cells</subject><subject>Amacrine Cells - cytology</subject><subject>Amacrine Cells - metabolism</subject><subject>Amacrine Cells - physiology</subject><subject>Animals</subject><subject>Assembly</subject><subject>Biological and medical sciences</subject><subject>Cellular</subject><subject>Circuits</subject><subject>Dendrites - metabolism</subject><subject>Dendrites - physiology</subject><subject>Exhibits</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. 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Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>Light</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Molecular biology</topic><topic>Motion</topic><topic>Motion Perception</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurons</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>RESEARCH ARTICLE SUMMARY</topic><topic>Retina</topic><topic>Retina - metabolism</topic><topic>Retina - physiology</topic><topic>Semaphorins - genetics</topic><topic>Semaphorins - metabolism</topic><topic>Signal Transduction</topic><topic>Sun</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Stimuli</topic><topic>Wiring</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Lu O.</creatorcontrib><creatorcontrib>Jiang, Zheng</creatorcontrib><creatorcontrib>Rivlin-Etzion, Michal</creatorcontrib><creatorcontrib>Hand, Randal</creatorcontrib><creatorcontrib>Brady, Colleen M.</creatorcontrib><creatorcontrib>Matsuoka, Ryota L.</creatorcontrib><creatorcontrib>Yau, King-Wai</creatorcontrib><creatorcontrib>Feller, Maria B.</creatorcontrib><creatorcontrib>Kolodkin, Alex L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Lu O.</au><au>Jiang, Zheng</au><au>Rivlin-Etzion, Michal</au><au>Hand, Randal</au><au>Brady, Colleen M.</au><au>Matsuoka, Ryota L.</au><au>Yau, King-Wai</au><au>Feller, Maria B.</au><au>Kolodkin, Alex L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>342</volume><issue>6158</issue><spage>590</spage><epage>590</epage><pages>590-590</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>24179230</pmid><doi>10.1126/science.1241974</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.590-590 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amacrine cells Amacrine Cells - cytology Amacrine Cells - metabolism Amacrine Cells - physiology Animals Assembly Biological and medical sciences Cellular Circuits Dendrites - metabolism Dendrites - physiology Exhibits Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Ganglia Light Mice Mice, Mutant Strains Molecular biology Motion Motion Perception Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RESEARCH ARTICLE SUMMARY Retina Retina - metabolism Retina - physiology Semaphorins - genetics Semaphorins - metabolism Signal Transduction Sun Vertebrates: nervous system and sense organs Visual Stimuli Wiring |
| title | On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms |
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