Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

B lymphocytes play a pivotal role in multiple sclerosis pathology, possibly via both antibody-dependent and -independent pathways. Intrathecal immunoglobulin G in multiple sclerosis is produced by clonally expanded B-cell populations. Recent studies indicate that the complementarity determining regi...

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Veröffentlicht in:	Molecular & cellular proteomics 2013-12, Vol.12 (12), p.3924-3934
Hauptverfasser:	Singh, Vaibhav, Stoop, Marcel P., Stingl, Christoph, Luitwieler, Ronald L., Dekker, Lennard J., van Duijn, Martijn M., Kreft, Karim L., Luider, Theo M., Hintzen, Rogier Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Sequence B-Lymphocytes - immunology B-Lymphocytes - pathology Case-Control Studies Chemical Fractionation Complementarity Determining Regions - cerebrospinal fluid Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology Electrophoresis, Polyacrylamide Gel Female Humans Immunoglobulin G - cerebrospinal fluid Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin Heavy Chains - cerebrospinal fluid Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin Light Chains - cerebrospinal fluid Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - immunology Male Mass Spectrometry Middle Aged Molecular Sequence Data Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Mutation
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