Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer

Background: We evaluated the clinical prognostic value of methylation of two non-coding repeat sequences, long interspersed element 1 (LINE-1) and Alu, in rectal tumour tissues. In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this patient cohort...

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Veröffentlicht in:	British journal of cancer 2013-12, Vol.109 (12), p.3073-3083
Hauptverfasser:	Benard, A, van de Velde, C J H, Lessard, L, Putter, H, Takeshima, L, Kuppen, P J K, Hoon, D S B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/2487/2486 692/699/67/1504/1885/1777 692/700/1750 Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Clinical outcomes Clinical Trials as Topic Deoxyribonuclease I - genetics DNA Methylation DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Drug Resistance Epidemiology Epigenomics Female Formaldehyde Gastroenterology. Liver. Pancreas. Abdomen Histones - genetics Histones - metabolism Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Paraffin Embedding Prognosis Rectal Neoplasms - genetics Repetitive Sequences, Nucleic Acid Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissue Fixation Treatment Outcome Tumors
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