Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice

Growth hormone receptor-null (GHR(-/-)) mice are dwarf, insulin sensitive, and long-lived in spite of increased adiposity. However, their adiposity is not uniform, with select white adipose tissue (WAT) depots enlarged. To study WAT depot-specific effects on insulin sensitivity and life span, we ana...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2014-01, Vol.69 (1), p.34-43
Hauptverfasser:	Sackmann-Sala, Lucila, Berryman, Darlene E, Lubbers, Ellen R, Zhang, Han, Vesel, Clare B, Troike, Katie M, Gosney, Elahu S, List, Edward O, Kopchick, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Adipose Tissue, White - metabolism Aging - physiology Animals Blotting, Western Cytoskeleton Disease Models, Animal DNA - genetics Electrophoresis, Gel, Two-Dimensional Gene Expression Regulation, Developmental Genotype & phenotype Growth hormones Insulin Insulin Resistance Male Mice Mice, Inbred C57BL Obesity - genetics Obesity - metabolism Original Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Rodents Tissues
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