Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects

Abstract Low cerebrospinal fluid (CSF) Aβ42 levels correlate with increased brain Aβ deposition in Alzheimer's disease (AD), which suggests a disruption in the degradation and clearance of Aβ from the brain. In addition, APOE ε4 carriers have lower CSF Aβ42 levels than non-carriers. The hypothe...

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Veröffentlicht in:	Neurobiology of aging 2014-02, Vol.35 (2), p.357-364
Hauptverfasser:	Millard, Steven P, Lutz, Franziska, Li, Ge, Galasko, Douglas R, Farlow, Martin R, Quinn, Joseph F, Kaye, Jeffrey A, Leverenz, James B, Tsuang, Debby, Yu, Chang-En, Peskind, Elaine R, Bekris, Lynn M
Format:	Artikel
Sprache:	eng
Schlagworte:	A2M Aged Aged, 80 and over alpha-2-Macroglobulin alpha-Macroglobulins - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Peptides - metabolism APOE Apolipoprotein E4 - genetics Aβ42 Brain - metabolism Cerebrospinal fluid Female Genotype Heterozygote Humans Internal Medicine Male Middle Aged Neurology Peptide Fragments - cerebrospinal fluid Peptide Fragments - metabolism Polymorphism, Single Nucleotide Proteolysis
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