Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre
Hepatitis C virus (HCV) genotyping is important for treatment and epidemiological purposes. The objective was to determine HCV genotype and their associations with certain risk factors at University Kebangsaan Malaysia Medical Centre (UKMMC). A total of 89 samples were collected from December 2009 t...
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| Veröffentlicht in: | Pakistan Journal of Medical Sciences 2013-09, Vol.29 (5), p.1142-1146 |
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| creator | Mohamed, N A Zainol Rashid, Z Wong, K K S A, Abdullah Rahman, M M |
| description | Hepatitis C virus (HCV) genotyping is important for treatment and epidemiological purposes. The objective was to determine HCV genotype and their associations with certain risk factors at University Kebangsaan Malaysia Medical Centre (UKMMC).
A total of 89 samples were collected from December 2009 to January 2011. Demographic data of patients were collected from medical record. Reverse Transcriptase Polymerase chain reaction (RT PCR) was performed and sixty-four samples yielded positive for HCV. Sequencing was performed and analyzed based on sequence information in GenBank. Statistical analysis were done using SPSS version 15. Results : HCV genotype 3 (73%) was the most frequent genotype, followed by genotype 1(27%). The distribution of HCV genotype/ subtype was as follows: 3a (64.8%), 1a (13.5%), 1 (10.8%), 3 (8.1%) and 1b (2.7%).
HCV subtypes 3a, 1a, and 1b were identified in patients at UKMMC, Malaysia with subtype 3a being the most prevalent. No significant association was found between HCV genotypes and patients' demographic data. |
| doi_str_mv | 10.12669/pjms.295.3610 |
| format | Article |
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A total of 89 samples were collected from December 2009 to January 2011. Demographic data of patients were collected from medical record. Reverse Transcriptase Polymerase chain reaction (RT PCR) was performed and sixty-four samples yielded positive for HCV. Sequencing was performed and analyzed based on sequence information in GenBank. Statistical analysis were done using SPSS version 15. Results : HCV genotype 3 (73%) was the most frequent genotype, followed by genotype 1(27%). The distribution of HCV genotype/ subtype was as follows: 3a (64.8%), 1a (13.5%), 1 (10.8%), 3 (8.1%) and 1b (2.7%).
HCV subtypes 3a, 1a, and 1b were identified in patients at UKMMC, Malaysia with subtype 3a being the most prevalent. No significant association was found between HCV genotypes and patients' demographic data.</description><identifier>ISSN: 1682-024X</identifier><identifier>ISSN: 1681-715X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.295.3610</identifier><identifier>PMID: 24353708</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>DNA polymerases ; Genetic aspects ; Hepatitis C virus ; Malaysia ; Medical centers ; Original ; Universities and colleges</subject><ispartof>Pakistan Journal of Medical Sciences, 2013-09, Vol.29 (5), p.1142-1146</ispartof><rights>COPYRIGHT 2013 Knowledge Bylanes</rights><rights>Copyright AsiaNet Pakistan (Pvt) Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-d19421ab52160669b2bd38eaa49696c8418e7a18df35c8c4f6e2b5e4f49a3b243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858944/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858944/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24353708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, N A</creatorcontrib><creatorcontrib>Zainol Rashid, Z</creatorcontrib><creatorcontrib>Wong, K K</creatorcontrib><creatorcontrib>S A, Abdullah</creatorcontrib><creatorcontrib>Rahman, M M</creatorcontrib><title>Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre</title><title>Pakistan Journal of Medical Sciences</title><addtitle>Pak J Med Sci</addtitle><description>Hepatitis C virus (HCV) genotyping is important for treatment and epidemiological purposes. The objective was to determine HCV genotype and their associations with certain risk factors at University Kebangsaan Malaysia Medical Centre (UKMMC).
A total of 89 samples were collected from December 2009 to January 2011. Demographic data of patients were collected from medical record. Reverse Transcriptase Polymerase chain reaction (RT PCR) was performed and sixty-four samples yielded positive for HCV. Sequencing was performed and analyzed based on sequence information in GenBank. Statistical analysis were done using SPSS version 15. Results : HCV genotype 3 (73%) was the most frequent genotype, followed by genotype 1(27%). The distribution of HCV genotype/ subtype was as follows: 3a (64.8%), 1a (13.5%), 1 (10.8%), 3 (8.1%) and 1b (2.7%).
HCV subtypes 3a, 1a, and 1b were identified in patients at UKMMC, Malaysia with subtype 3a being the most prevalent. No significant association was found between HCV genotypes and patients' demographic data.</description><subject>DNA polymerases</subject><subject>Genetic aspects</subject><subject>Hepatitis C virus</subject><subject>Malaysia</subject><subject>Medical centers</subject><subject>Original</subject><subject>Universities and colleges</subject><issn>1682-024X</issn><issn>1681-715X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptks1v1DAQxSMEoqVw5YgsISEuWeLPOBekagUU0YoLlXqzJs5k10tiL7FTaf97nFJKiyofbI1_741m9IriNa1WlCnVfNjvxrhijVxxRasnxTFVmpY1lVdPb96srJi4OipexLirKqGEZM-LIya45HWljwt_hntILrlI1mSDPqTDHgn4jkCMwTpI2JHJxZ-R9GBTmCIJPVkk6FMkkMild9c4RZcO5Bu24DcRwJMLGOAQHZAL7JyFgawzP-HL4lkPQ8RXt_dJcfn504_1WXn-_cvX9el5aSVVqexoIxiFVjKqqjxly9qOawQQjWqU1YJqrIHqrufSait6hayVKHrRAG_zdCfFxz---7kdsbNLcxjMfnIjTAcTwJmHP95tzSZcG66lbsRi8P7WYAq_ZozJjC5aHAbwGOZoqGiqmtO60Rl9-x-6C_Pk83iGSim5rpmm_6gNDGic70PuaxdTc8pryZjQSmZq9QiVT4ejs8Fj73L9geDdPcEWYUjbGIY5ueDjo852CjFO2N8tg1bmJkpmiZLJUTJLlLLgzf0V3uF_s8N_A-9exL0</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Mohamed, N A</creator><creator>Zainol Rashid, Z</creator><creator>Wong, K K</creator><creator>S A, Abdullah</creator><creator>Rahman, M M</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publicaitons</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre</title><author>Mohamed, N A ; Zainol Rashid, Z ; Wong, K K ; S A, Abdullah ; Rahman, M M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-d19421ab52160669b2bd38eaa49696c8418e7a18df35c8c4f6e2b5e4f49a3b243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>DNA polymerases</topic><topic>Genetic aspects</topic><topic>Hepatitis C virus</topic><topic>Malaysia</topic><topic>Medical centers</topic><topic>Original</topic><topic>Universities and colleges</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, N A</creatorcontrib><creatorcontrib>Zainol Rashid, Z</creatorcontrib><creatorcontrib>Wong, K K</creatorcontrib><creatorcontrib>S A, Abdullah</creatorcontrib><creatorcontrib>Rahman, M M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan Journal of Medical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, N A</au><au>Zainol Rashid, Z</au><au>Wong, K K</au><au>S A, Abdullah</au><au>Rahman, M M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre</atitle><jtitle>Pakistan Journal of Medical Sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>29</volume><issue>5</issue><spage>1142</spage><epage>1146</epage><pages>1142-1146</pages><issn>1682-024X</issn><issn>1681-715X</issn><eissn>1681-715X</eissn><abstract>Hepatitis C virus (HCV) genotyping is important for treatment and epidemiological purposes. The objective was to determine HCV genotype and their associations with certain risk factors at University Kebangsaan Malaysia Medical Centre (UKMMC).
A total of 89 samples were collected from December 2009 to January 2011. Demographic data of patients were collected from medical record. Reverse Transcriptase Polymerase chain reaction (RT PCR) was performed and sixty-four samples yielded positive for HCV. Sequencing was performed and analyzed based on sequence information in GenBank. Statistical analysis were done using SPSS version 15. Results : HCV genotype 3 (73%) was the most frequent genotype, followed by genotype 1(27%). The distribution of HCV genotype/ subtype was as follows: 3a (64.8%), 1a (13.5%), 1 (10.8%), 3 (8.1%) and 1b (2.7%).
HCV subtypes 3a, 1a, and 1b were identified in patients at UKMMC, Malaysia with subtype 3a being the most prevalent. No significant association was found between HCV genotypes and patients' demographic data.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>24353708</pmid><doi>10.12669/pjms.295.3610</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | DNA polymerases Genetic aspects Hepatitis C virus Malaysia Medical centers Original Universities and colleges |
| title | Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre |
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