Completion of the entire hepatitis C virus life cycle in genetically humanized mice

The entire hepatitis C virus life cycle can be recapitulated in an inbred mouse model, allowing preclinical assessment of antiviral therapeutics and vaccines. Humanized mouse model for hepatitis C infection In a 2009 Nature paper, Alexander Ploss and colleagues showed that transient expression of th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2013-09, Vol.501 (7466), p.237-241
Hauptverfasser:	Dorner, Marcus, Horwitz, Joshua A., Donovan, Bridget M., Labitt, Rachael N., Budell, William C., Friling, Tamar, Vogt, Alexander, Catanese, Maria Teresa, Satoh, Takashi, Kawai, Taro, Akira, Shizuo, Law, Mansun, Rice, Charles M., Ploss, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596/1905 Animal models Animals Cell Line Cyclophilin A - genetics Cyclophilin A - metabolism Disease Models, Animal DNA sequencing Genetic aspects Genetic Engineering Genomes Hepacivirus - immunology Hepacivirus - physiology Hepatitis Hepatitis C - genetics Hepatitis C - immunology Hepatitis C - virology Hepatitis C virus Human factors Humanities and Social Sciences Humans Immune system Infections letter Life cycles Methods Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Nucleotide sequencing Occludin - genetics Occludin - metabolism Rodents Science STAT1 Transcription Factor - deficiency Tetraspanin 28 - genetics Tetraspanin 28 - metabolism Vaccines Viremia - virology Virion - growth & development Virion - physiology Virus Replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!